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Effect of shuxinyin on in-stent restenosis after coronary artery stenting

  • Xian Wang
  • Zhong-xiang Lin
  • Jun-bo Ge
  • Xu Liu
  • Yan He
  • Zhen-xian Zhang
  • lin Shen
Article
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Abstract

Objective

To evaluate the effect of anti-platelet regimens and it’s combination with Shuxinyin (SXY,) on in-stent restenosis after stent implantation.

Methods

Forty-four patients with successful stent implantation in a coronary artery were randomly assigned to the treated group (n = 20) and the control group (n = 24). The treated group received SXY and anti-platelet therapy. The control group were treated with anti-platelet regimens only. Platelet activation was assessed before and immediately after the stenting by flow cy-tometry, the expression of P-selectin (CD62P) and glycoprotein(GP) П b/Ш a receptor. It was reassessed on the 30th day after stenting. Plasma fibrinogen (Fg) and C-reaction protein (CRP) were measured by biuret and laser scattering turbidimetry respectively at the same time. Observation was made on the scoring of the symptoms of Qi deficiency syndrome, Qi-Yin deficiency syndrome and blood stasis syndrome in the two groups. Differences between groups were compared.

Results

Compared with the control group, combination with SXY and anti-platelet therapy was remarkable in reducing plasma CRP (P < 0.05), and also with the tendency to decrease plasma Fg, GP П b/Шa and CD62P. It could also evidently decrease the scoring of Qi-Yin deficiency syndrome, Qi deficiency syndrome and blood stasis syndrome after stenting (P <0.05, 0.01, 0.01) respectively. Followup survey found 40 % relapse of angina pectoris with 4 cases of in-stent restenosis proved by angiography in the treated group. But the relapse of angina pectoris in the control group was 67% with 2 cases of mypcardial infarction (MI), 7 cases of in-stent restenosis proved by angiography and one death.

Conclusions

Combination with SXY and anti-platelet regimens can prevent stent thrombosis and in-stent restenosis after stent implantation, and it seems superior to anti-platelet therapy only.

Key words

angioplasty stenting in-stent restenosis platelets glycoprotein Shuxinyin 

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References

  1. 1.
    Neumann FJ, Gawaz M, Ott I, et al. Anti-platelet effect of ticlopidine after coronary stenting. J Am Coll Cardiol 1997; 29:1515–1519.PubMedCrossRefGoogle Scholar
  2. 2.
    Rupprecht HJ, Darius H, Borkowski U, et al. Comparison of anti-platelet effects of aspirin, ticlopidine, or their combination after stent implantion. Circulation 1998; 97:1046–1052.PubMedGoogle Scholar
  3. 3.
    Ma CS, Gai LY, Zhang KJ, et al. Intervention heart disease. 1st edition. Beijing: The People’s Health Publishing House, 1998:335–336.Google Scholar
  4. 4.
    Gawaz M, Neumann FJ, Ott I, et al. Platelet activation and coronary stent implantation. Circulation 1996; 94 (3): 279–285.PubMedGoogle Scholar
  5. 5.
    Cardioangiology Committee of Chinese Association of the Integration of Traditional and Western Medicine. Criteria for syndrome differentiation of coronary heart disease. Chin J Integr Med 1991;11(5):257.Google Scholar
  6. 6.
    The Committee of Study on Deficiency Syndrome and Senile Disease of Chinese Association of the Integration of Traditional and Western Medicine. The reference criteria for differentiation of deficiency syndrome. Chin J Integr Med 1986;6(10):598.Google Scholar
  7. 7.
    The Committee of Promoting Blood Circulation to Remove Stasis, China Association of the Integration of Traditional and Western Medicine. Criteria for syndrome differentiation of blood stasis syndrome. Chin J Integr Med 1987; 7(3): 129.Google Scholar
  8. 8.
    Wang J, Chen KJ, Weng WL, et al. Study on the criteria for diagnosis of blood stasis syndrome. Chin J Integr Med 1988;8(10):585–589.Google Scholar

Copyright information

© The Chinese Journal of Integrated Traditional and Western Medicine Press 2002

Authors and Affiliations

  • Xian Wang
    • 1
  • Zhong-xiang Lin
    • 2
  • Jun-bo Ge
    • 3
  • Xu Liu
    • 4
  • Yan He
    • 2
  • Zhen-xian Zhang
    • 2
  • lin Shen
    • 2
  1. 1.Department of CardiologyBeijing Hospital of Integrated Traditional and Western MedicineBeijing
  2. 2.Long-hua Hospital Affiliated to Shanghai TCM UniversityUSA
  3. 3.Zhongs-han Hospital Affiliated to Fudan UniversityUSA
  4. 4.Shanghai Chest HospitalUSA

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