Effect of electroacupuncture on pulmonary β-adrenoceptor in allergic asthma guinea-pigs
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Twenty four male guinea-pigs were randomly divided into 3 groups: Group A, allergic asthma guinea-pigs prepared by peritoneal injection and spraying inhalation of albumin; Group B, allergic asthma guinea-pigs treated with electroacupuncture through stimulating the acupoint Feishu (UB13) and Group C, the control group. With[3H]-DHA as a radioligand, pulmonary β-adrenoceptor (β- AC) in the 3 groups of guineapigs were detrermined by radioligand binding assay technique. The results showed that: (1) The maximum binding volume of receptor ligand (Bmax, fmol/mg prot.) of pulmonary β-AC in Group A (123.86 β 42.91) was significantly lower than that in group C (199.54 β 37.03,P<0.05), while the difference between group B (142.00+42.91) and group C was not significant (P>0.05). (2) The Kd (nM) of pulmonary β-AC in group A, B and C were 5.10 β 1.39, 6.53 β 2.41 and 8.72 β 2.02 respectively, and the differences among the three groups were not significant (P>0.05). The results indicated that the decrease of the content and dysfunction of pulmonary β-AC in allergic asthma guinea-pigs might be regulated by electroacupuncture therapy.
Key Wordspulmonary β-adrenoceptor electroacupuncture allergic asthma radioligand binding assay maximum binding volume of receptor ligand equilibrium dissociation constant
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