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Medical Oncology and Tumor Pharmacotherapy

, Volume 1, Issue 3, pp 193–194 | Cite as

Plasma pharmacokinetics of adriamycin after intrapleural administration

  • Staffan Eksborg
  • Astrid Lindfors
  • Björn J. Cedermark
Article
  • 17 Downloads

Abstract

The plasma pharmacokinetics of adriamycin after intrapleural administration have been studied. The maximum plasma concentration found after intrapleural instillation of 50 mg was 100 ng ml−1, the adriamycin half-life being about 2.5 h.

Large amounts of the drug are adsorbed from the pleura. Hence risks for cardiomyopathy, previously associated with the repeated intravenous administration of adriamycin, must also be considered after intrapleural administration.

Key words

Adriamycin Intrapleural Cancer Chemotherapy Pharmacokinetics Pleural effusions 

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Copyright information

© Humana Press Inc. 1984

Authors and Affiliations

  • Staffan Eksborg
    • 1
  • Astrid Lindfors
    • 1
  • Björn J. Cedermark
    • 2
  1. 1.Karolinska PharmacyStockholmSweden
  2. 2.Department of SurgeryKarolinska HospitalStockholmSweden

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