Journal of Gastroenterology

, Volume 32, Issue 5, pp 643–649 | Cite as

Gastric neuroendocrine carcinoma associated with chronic atrophic gastritis type A

  • Yasuharu Kaizaki
  • Takeshi Fujii
  • Toshiro Kawai
  • Ken Saito
  • Katsumi Kurihara
  • Masashi Fukayama
Case Report


We report a case of gastric neuroendocrine (NE) carcinoma associated with chronic atrophic gastritis type A (CAG/A) or reversed atrophic type gastritis. A 9 × 6 cm tumor was resected from the stomach to control pain in a 55-year-old Japanese woman with peritoneal dissemination and metastatic tumors of the liver and ovary. Histologically, the tumor was NE carcinoma which showed an organoid structure, but consisted of NE Cells with overt cytological atypia and frequent mitotic activity. Multiple microcarcinoids and NE cell micronests (NECMs) were also observed in the atrophic non-neoplastic mucosa of the gastric body. CEA immunoreactivity and a high Ki-67 labeling index were characteristic features of the neoplastic NE cells of the carcinoma. Although most NE tumors arising from CAG/A are typical carcinoid tumors, the present case illustrates that a high-grade NE carcinoma can develop from diverse NE cell proliferation in association with CAG/A.

Key words

gastric neuroendocrine carcinoma chronic atrophic gastritis type A (CAG/A) gastric carcinoid tumor neuroendocrine cell micronest (NECM) 


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Copyright information

© Springer-Verlag 1997

Authors and Affiliations

  • Yasuharu Kaizaki
    • 1
  • Takeshi Fujii
    • 1
  • Toshiro Kawai
    • 1
  • Ken Saito
    • 1
  • Katsumi Kurihara
    • 2
  • Masashi Fukayama
    • 1
  1. 1.Department of PathologyJichi Medical SchoolTochigiJapan
  2. 2.Department of General SurgeryJichi Medical SchoolTochigiJapan

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