Folia Microbiologica

, Volume 37, Issue 3, pp 237–238 | Cite as

Screening for a new generation of anthelminthic compounds.In vitro selection of the nematodeCaenorhabditis elegans for ivermectin resistance

  • J. Novák
  • Z. Vaněk
Brief Report


Development of resistance to ivermectinin vitro is reported for the first time. Two strains ofCaenorhabditis elegans D5 and D6 able to grow on agar plates after treating with up to 3 mg ivermectin per L were selected. The parent strain N2 was extremely sensitive to ivermectin, its growth being inhibited by treatment with 0.1–0.2 mg IVM per L.


Parent Strain Resistant Strain Ivermectin Wild Strain Abamectin 



4-aminobutyric acid




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Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic 1992

Authors and Affiliations

  • J. Novák
    • 1
  • Z. Vaněk
    • 1
  1. 1.Institute of MicrobiologyCzechoslovak Academy of SciencesPrague 4

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