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Virchows Archiv B

, Volume 40, Issue 1, pp 1–7 | Cite as

Ultrastructural localization of human complement C3b receptors in the human kidney as determined by immunoperoxidase staining with the monoclonal antibody C3RTo5

  • Johannes Gerdes
  • Martin-L. Hansmann
  • Harald Stein
  • Mohammed Naiem
  • David Y. Mason
Article

Summary

The precise localization of human complement C3b receptors in human kidneys was investigated by means of indirect immunoperoxidase staining of frozen kidney sections with the monoclonal antibody C3RT05, which is specific for human C3b receptors. Transmission electron microscopy indicated that C3b receptors are located on the entire cell membrane of the visceral epithelial cells of the glomeruli.

Key words

Renal glomeruli Podocytes Complement C3b receptors Monoclonal antibody 

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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • Johannes Gerdes
    • 1
  • Martin-L. Hansmann
    • 1
  • Harald Stein
    • 1
  • Mohammed Naiem
    • 2
  • David Y. Mason
    • 2
  1. 1.Institut für PathologieChristian-Albrechts-UniversitätKielFederal Republic of Germany
  2. 2.Nuffield Department of PathologyUniversity of Oxford, John Radcliffe HospitalOxfordGreat Britain

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