Folia Microbiologica

, Volume 52, Issue 1, pp 39–43 | Cite as

Effect of subinhibitory concentration of some established and experimental antifungal compounds on the germ tube formation inCandida albicans

  • L. A. Vale-Silva
  • V. Buchta
  • E. Valentová


The influence of subinhibitory concentrations of six established and 19 newly synthesized antifungal compounds on the dimorphic transition of threeC. albicans strains was evaluated in the filamentation-inducing medium. Amphotericin B was found to produce almost complete inhibition in the germination at a concentration of 1/10 of the corresponding MIC and partial inhibition at a concentration as low as MIC/50. Flucytosine and four azole derivatives were proven ineffective. From the newly synthesized drugs, the incrustoporin derivative LNO6-22, two phenylguanidine derivatives (PG15, PG45), and four thiosalicylanilide derivatives, in particular, showed results comparable to those of amphotericin B, with a high inhibition of germ tube formation at concentrations of MIC/10. In general, concentrations of MIC/50 had no visible effect.


Fluconazole Candida Albicans Germ Tube Antifungal Compound Flucytosine 
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subinhibitory concentration(s)


minimum inhibitory concentration(s)


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Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic 2007

Authors and Affiliations

  1. 1.Department of Biological and Medical Sciences, Faculty of PharmacyCharles UniversityHradec KrálovéCzechia
  2. 2.Department of Clinical MicrobiologyUniversity Hospital, Charles UniversityHradec KrálovéCzechia

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