Folia Microbiologica

, 52:26 | Cite as

Relationship between volatile odorous substances and production of avermectins byStreptomyces avermitilis



The time course of production of odorous compounds,i.e. geosmin and oxolones, and of avermectins was determined during the cultivation ofS. avermitilis in flasks, 1- and 50-L fermentors. The amount of the antibiotics increased with increasing cultivation time up to more than 2 g/L while the concentration of geosmin rose to more than 4 mg/L. Cultivation without reflux condenser resulted in a lower product formation due to the higher stripping of geosmin. A relatively tight correlation was found between the production of geosmin and the production of avermectins. The production of oxolones peaked on cultivation days 3–5, the sum of oxolones being 60 µg/L. Subsequently, the production dropped below a measurable level. This can be explained as being due to the inhibition of oxolone production by geosmin.


Streptomyces Reflux Condenser Volatile Substance Geosmin Odorous Compound 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.









  1. Běhal V.: Mode of action of microbial bioactive metabolites.Folia Microbiol. 51, 359–369 (2006).CrossRefGoogle Scholar
  2. Cane D.E., He X.F., Kobayashi S., Omura S., Ikeda H.: Geosmin biosynthesis inStreptomyces avermitilis. Molecular cloning, expression, and mechanistic study of the germacradienol/geosmin synthase.J.Antibiot. 59, 471–479 (2006).PubMedCrossRefGoogle Scholar
  3. Dougherty J.D., Campbell R.D., Moris R.L.: Actinomycetes: isolation and identification of agent responsible for musty odors.Science 152, 1372–1373 (1966).PubMedCrossRefGoogle Scholar
  4. Gerber N.N.: Geosmin, from microorganisms istrans-1,10-dimethyl-trans-9-decalol.Tetrahedron Lett. 25, 2971–2974 (1968).CrossRefGoogle Scholar
  5. Gerber N.N.: Volatile lactones fromStreptomyces.Tetrahedron Lett. 10, 771–774 (1973).CrossRefGoogle Scholar
  6. Gerber N.N., Lechevalier H.A.: Geosmin, a earthy-smelling substance isolated from actinomycetes.Appl.Microbiol. 13, 935–938 (1965).PubMedGoogle Scholar
  7. Jáchymová J., Votruba J., Víden I., Řezanka T.: Identification ofStreptomyces odor spectrum.Folia Microbiol. 47, 37–41 (2002).CrossRefGoogle Scholar
  8. Janeček J., Tichý P., Spížek J., Vaněk Z.: Constitution of the metabolic type of streptomycetes during the first hours of cultivation.Folia Microbiol. 42, 75–96 (1997).CrossRefGoogle Scholar
  9. Ostash B., Kozarevska I., Fedorenko V.: Generation of landomycin D-producing strainStreptomyces globisporus LD3.Folia Microbiol. 50, 19–23 (2005).CrossRefGoogle Scholar
  10. Petrova D., Derekova A., Vlahov S.: Purification and properties of individual collagenases fromStreptomyces sp. strain 3B.Folia Microbiol. 51, 93–99 (2006).CrossRefGoogle Scholar
  11. Řezanka T., Sigler K.: Volatile lactones — (5S,S)-5-methyl-3-(methylalkyl)furan-2(5H)-ones — identified in the submerged cultivation ofStreptomyces avermitilis. Eur.J.Org.Chem. 4277–4284 (2006).Google Scholar
  12. Řezanka T., Votruba J.: Effect of salinity on the formation of avermectins, odor compounds and fatty acids byStreptomyces avermitilis.Folia Microbiol. 43, 47–50 (1998a).CrossRefGoogle Scholar
  13. Řezanka T., Votruba J.: Fermentation odor and bioreactor scale-up.Bioproc.Eng. 19, 159–160 (1998b).CrossRefGoogle Scholar
  14. Řezanka T., Líbalová D., Votruba J., Víden I.: Identification of odorous compounds fromStreptomyces avermitilis.Biotechnol. Lett. 16, 75–76 (1994).CrossRefGoogle Scholar
  15. Schrader K.K., Blevins W.T.: Effects of selected environmental conditions on biomass and geosmin production byStreptomyces halstedii.J.Microbiol. 37, 159–167 (1999).Google Scholar
  16. Schrader K.K., Blevins W.T.: Effects of carbon source, phosphorus concentration, and several micronutrients on biomass and geosmin production byStreptomyces halstedii.J.Ind.Microbiol.Biotechnol. 26, 241–247 (2001).PubMedCrossRefGoogle Scholar

Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic 2007

Authors and Affiliations

  1. 1.Institute of MicrobiologyAcademy of Sciences of the Czech RepublicPrague

Personalised recommendations