Folia Microbiologica

, 52:525 | Cite as

Neisseria meningitidis strains from patients with invasive meningococcal disease differ in stimulation of cytokine production

  • M. Holub
  • M. Scheinostová
  • O. Džupová
  • A. Fišerová
  • O. Beran
  • J. Kalmusová
  • M. Musílek
  • P. Křížová


Cytokine production was determinedin vitro after stimulation with three differentNeisseria meningitidis (NM) strains. Virulent NM B strain isolated from a patient with mild course of invasive meningococcal disease (IMD) elicited higher cytokine production than NM B and NM C hypervirulent strains isolated from patients with moderate and fatal course of IMD, respectively. Endotoxin concentration afterin vitro stimulation correlated with cytokine production: the highest endotoxin levels were observed with virulent NM B strain. Serum cytokines and endotoxin levels showed an opposite trend. These results suggest that inflammatory response during IMD is predominantly influenced by host factors.


Cytokine Production Meningococcal Disease Neisseria Meningitidis Endotoxin Level Endotoxin Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



acute physiological and chronic health evaluation


C-reactive protein


flow cytometer


fulminant meningococcal sepsis




invasive meningococcal disease




multilocus sequence typing


Neisseria meningitidis


serum bactericidal assay with the use of baby rabbit complement


sepsis organ failure assessment


tumor necrosis factor α


whole blood


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Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic 2007

Authors and Affiliations

  • M. Holub
    • 1
  • M. Scheinostová
    • 1
  • O. Džupová
    • 2
  • A. Fišerová
    • 1
  • O. Beran
    • 1
  • J. Kalmusová
    • 3
  • M. Musílek
    • 3
  • P. Křížová
    • 3
  1. 1.3rd Department of Infectious and Tropical Diseases, 1st Faculty of MedicineCharles University in PraguePragueCzechia
  2. 2.Department of Infectious Diseases, 3rd Faculty of MedicineCharles University in PraguePragueCzechia
  3. 3.National Reference Laboratory for Meningococcal InfectionsNational Institute of Public HealthPragueCzechia

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