Hibernation of mammalian cells at a living body temperature



The present study revealed that polyphenol induces the hibernation of mammalian cells at a living body temperature. It was found that polyphenol is a cytostatic-sleeping agent for mammalian cells, where almost all cells resume proliferation after the hibernation period and cell death seldom occurs. By changing the concentration of polyphenol, various mammalian cells can be stored under different conditions, such as temporary sleep, sound sleep, and hibernation conditions.


hibernation polyphenol cytostatic proliferation cryopreservation mammalian cell 


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Copyright information

© The Korean Society for Biotechnology and Bioengineering 2001

Authors and Affiliations

  1. 1.Institute for Frontier Medical SciencesKyoto UniversityKyotoJapan

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