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Journal of Genetics

, Volume 66, Issue 2, pp 133–138 | Cite as

Genetic variability of complement receptor on human erythrocytes

  • Jerzy S Nowak
Article

Abstract

Erythrocytes from healthy men were examined for the presence of complement (C3b) receptor using haemagglutination assay with human aggregated IgG (aggIgG) and guinea pig complement. The results were expressed as the intensity of haemagglutination that corresponded to the C3b receptor sites density as evidenced by radioimmunobinding results. Among normal men three phenotypes of complement receptor (CR) were distinguished: high (CRh/CRh) phenotype corresponding to strong agglutination, an intermediate (CRh/CRI) producing weak agglutination and low phenotype (CRI/CRI) that gave no agglutination. In a population of 517 normal men these three phenotypes occurred in 63.8, 30.6 and 5.6%, respectively. Frequencies of the genes responsible for high (CRh) and low (CRI) expression of erythrocyte C3b receptor were 0.791 and 0.209, respectively.

Keywords

C3b receptor erythrocytes genetic variability 

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Copyright information

© Indian Academy of Sciences 1987

Authors and Affiliations

  • Jerzy S Nowak
    • 1
  1. 1.Institute of Human GeneticsPolish Academy of SciencesPoznańPoland

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