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Experimental colitis does not increase the prevalence of ANKENT, a spontaneous joint disease in mice

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Abstract

A possible relationship between intestinal inflammation and joint disease development was investigated. Clinical symptoms of colitis — diarrhea and rectal bleeding — were confirmed by findings of inflammatory processes in the colon in dextran sodium sulfate-treated mice and joint ankylosing enthesopathy (ANKENT) developed in 12.8% mice with chronic colitis and 13.6% mice in the control group. Consequently no significant difference in ANKENT frequency was found between mice with and without chronic colitis and the occurrence of ANKENT in both groups was typical for conventional conditions. ANKENT cannot be triggered solely a generalized inflammatory process in the gut.

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Abbreviations

ANKENT:

ankylosing enthesopathy

CV:

conventional

GF:

germ-free

MHC I:

major histocompatibility complex, class I

AS:

ankylosing spondylitis

DSS:

dextran sodium sulfate

IBD:

inflammatory bowel disease

SPF:

specific-pathogen-free

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Authors and Affiliations

  1. Department of Biology and Biochemistry of Reproduction, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, 142 20, Prague, Czechia

    J. Čapková

  2. Department of Immunology and Gnotobiology, Institute of Microbiology, Academy of Sciences of the Czech Republic, 549 22, Nový Hrádek, Czechia

    R. Štěpánková, T. Hudcovic, J. Šinkora & Z. Řeháková

Authors
  1. J. Čapková
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  2. R. Štěpánková
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  3. T. Hudcovic
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  4. J. Šinkora
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  5. Z. Řeháková
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Corresponding author

Correspondence to J. Čapková.

Additional information

This work was supported by grants no. 310/00/1371 and 305/03/0287 of theGrant Agency of the Czech Republic.

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Čapková, J., Štěpánková, R., Hudcovic, T. et al. Experimental colitis does not increase the prevalence of ANKENT, a spontaneous joint disease in mice. Folia Microbiol 49, 745–750 (2004). https://doi.org/10.1007/BF02931559

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  • DOI: https://doi.org/10.1007/BF02931559

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