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Folia Microbiologica

, 51:21 | Cite as

QSAR study of antimycobacterial activity of quaternary ammonium salts of piperidinylethyl esters of alkoxysubstituted phenylcarbamic acids

  • K. Waisser
  • R. Doležal
  • K. Palát
  • J. Čižmárik
  • J. Kaustová
Article

Abstract

A series of 17 halogenides of quaternary ammonium salts of the alkylpiperidinylethyl esters of 2-pentoxy (and 2-heptoxy) substituted phenylcarbamic acids were evaluated forin vitro antimycobacterial activity againstMycobacterium tuberculosis, M. kansasii, andM. avium. Correlation of this action with lipophilicity (logP, 1-octanol-water system) was used for the description of the structure-antimycobacterial activity relationships (QSARs). The activity increased with the increasing lipophilicity of the compounds.

Keywords

Quaternary Ammonium Salt Antimycobacterial Activity Quaternary Salt Carbamic Acid Propyl Ester 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic 2006

Authors and Affiliations

  • K. Waisser
    • 1
  • R. Doležal
    • 1
  • K. Palát
    • 1
  • J. Čižmárik
    • 2
  • J. Kaustová
    • 3
  1. 1.Department of Inorganic and Organic Chemistry, Faculty of PharmacyCharles UniversityHradec KrálovéCzechia
  2. 2.Department of Pharmaceutical Chemistry, Faculty of PharmacyComenius UniversityBratislavaSlovakia
  3. 3.Department for Diagnostics of MycobacteriaRegional Institute of Public Health, OstravaOstravaCzechia

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