Folia Microbiologica

, 50:473 | Cite as

Antimicrobial activity of ZnII, CdII, and HgII complexes of 1,2-bis-[2-(5-R)-1H-benzimidazolyl]-1,2-ethanediols and 1,4-bis-[2-(5-R)-1H-benzimidazolyl]-1,2,3,4-butanetetraols

  • A. Tavman
  • S. Birteksöz
  • G. Ötük


1,2-Bis-[2-(5-H/Me/Cl/NO2)-1H-benzimidazolyl]-1,2-ethanediols (L 1L 4), 1,4-bis-[2-(5-H/Me/Cl)-1H-benzimidazolyl]-1,2,3,4-butanetetraols (L 5L 7) and their complexes with ZnCl2, CdCl2 and HgCl2 were synthesized and antibacterial activity of the compounds was tested towardStaphylococcus aureus, S. epidermidis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Shigella flexneri, Proteus mirabilis and antifungal activity againstCandida albicans. HgII complexes have a considerably higher antimicrobial activity against all microorganisms. Some HgII complexes show higher antifungal activity than clotrimazole towardC. albicans. Zn2(L 3)Cl4, Zn2(L 4)Cl4, and Cd(L 3)Cl2 were moderately effective againstS. aureus andS. epidermidis; Cd(L 4)Cl2 exhibited a weak activity only againstS. epidermidis.


Antimicrobial Activity Benzimidazole Clotrimazole Benzimidazole Derivative Shigella Flexneri 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic 2005

Authors and Affiliations

  • A. Tavman
    • 1
  • S. Birteksöz
    • 2
  • G. Ötük
    • 2
  1. 1.Department of Chemistry, Faculty of EngineeringIstanbul UniversityAvcilar, IstanbulTurkey
  2. 2.Department of Pharmaceutical Microbiology, Faculty of PharmacyIstanbul UniversityBeyazit, IstanbulTurkey

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