Abstract
A significantly higher frequency of apoptosis was documented by flow cytometry and by ELISA analysis, and significantly higher numbers of necrotic cells were demonstrated by ELISA within the thymus of Lurcher mice in comparison with the control C3H mice. These can be regarded as important markers of degenerative changes in this primary immune organ. This tendency is supported by histological observation of the absence of a clear interface between thymic cortex and medulla and an insignificantly increased number of HassalĽs corpuscles resembling an onset of thymic atrophy.
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This work was supported byGrant Agency of Czech Republic (grant 301/02/1232) and byInstitutional Research Concept no. AV 0Z 502 0903.
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Manďáková, P., Virtová, M., Šíma, P. et al. Congenitally determined neurodegeneration “lurcher” induces morphofunctional changes of thymus. Folia Microbiol 48, 394–398 (2003). https://doi.org/10.1007/BF02931373
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DOI: https://doi.org/10.1007/BF02931373