Folia Microbiologica

, 48:394 | Cite as

Congenitally determined neurodegeneration “lurcher” induces morphofunctional changes of thymus

  • P. Manďáková
  • M. Virtová
  • P. Šíma
  • M. Beranová
  • J. Slípka


A significantly higher frequency of apoptosis was documented by flow cytometry and by ELISA analysis, and significantly higher numbers of necrotic cells were demonstrated by ELISA within the thymus of Lurcher mice in comparison with the control C3H mice. These can be regarded as important markers of degenerative changes in this primary immune organ. This tendency is supported by histological observation of the absence of a clear interface between thymic cortex and medulla and an insignificantly increased number of HassalĽs corpuscles resembling an onset of thymic atrophy.


Necrotic Cell Caddy Thymic Cortex Thymic Microenvironment MORPHOFUNCTIONAL Change 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic 2003

Authors and Affiliations

  • P. Manďáková
    • 1
  • M. Virtová
    • 2
  • P. Šíma
    • 2
  • M. Beranová
    • 3
  • J. Slípka
    • 3
  1. 1.Department of Pathology and Molecular MedicineUniversity Hospital MotolPragueCzechia
  2. 2.Division of Immunology and Gnotobiology, Institute of MicrobiologyAcademy of Sciences of the Czech RepublicPragueCzechia
  3. 3.Institute of Histology and Embryology, Faculty of MedicineCharles UniversityPilsenCzechia

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