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The detection of anti-Candida antibodies on experimental animal models

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Abstract

The levels of anti-Candida antibodies were determined in experimental animals immunized with 4 different yeast doses (0.3, 0.6, 1.2, 2.4 × 108 CFU) at weekly intervals. After immunization (sampling intervals 1, 2, and 3 months), the intravenous blood was examined for the presence of serum anti-Candida antibodies. After one month, the titers of anti-Candida antibodies reached 1:40–1:1280 and remained at the same level after two months in the majority of animals; only in a few of them the titers increased or were detectedde novo. After three months, when the animals were no longer immunized, a decreasing trend in antibody titers was detected in the majority of animals.

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References

  • Buckley H.R., Richardson M.D., Evans E.G.V., Wheat L.J.: Immunodiagnosis of invasive fungal infection.J.Med.Vet.Mycol. 30, 249–260 (1992).

    Article  PubMed  Google Scholar 

  • Budtz-Jørgensen E.: Histopathology, immunology, and serology of oral yeast infections.Acta Odontol.Scand. 48, 37–43 (1990).

    Article  PubMed  Google Scholar 

  • Dorko E., Viragova S., Pilipčinec E., Tkáčiková L’.: Detection of anti-Candida antibodies in neonates from a neonatal intensive care unit.Folia Microbiol. 47, 297–301 (2002a).

    Article  CAS  Google Scholar 

  • Dorko E., Jenča A., Pilipčinec E., Tkáčiková L’.: The detection of anti-Candida antibodies by the indirect immunofluorescence assay in patients with cancer in the orofacial region.Folia Microbiol. 47, 732–736 (2002b).

    Article  CAS  Google Scholar 

  • Ferenčík M., Škárka B.:Biochemical Laboratory Methods. (In Slovak) Alfa Publishers, Bratislava (Slovakia) 1981.

    Google Scholar 

  • Garcia-Ruiz J.C., Arilla M.C., Regúlez P., Quindós G., Álvarez A., Pontón J.: Detection of antibodies toCandida albicans germ tube for diagnosis and therapeutic monitoring of invasive candidiasis in patients with hematologic malignancies.J.Clin. Microbiol. 35, 3284–3287 (1997).

    PubMed  CAS  Google Scholar 

  • Jones J.M.: Kinetics of antibody responses to cell wall mannan and a major cytoplasmatic antigen ofCandida albicans in rabbits and humans.J.Lab.Clin.Med. 96, 845–860 (1980).

    PubMed  CAS  Google Scholar 

  • Quindós G., Pontón J., Cisterna R., Mackenzie D.W.R.: Value of detection of antibodies toCandida albicans germ tube in the diagnosis of systemic candidosis.Eur.J.Clin.Microbiol.Infect.Dis. 9, 178–183 (1990).

    Article  PubMed  Google Scholar 

  • Tomšíková A.:Defence Mechanisms Found in Mycoses in Czechoslovakia. (In Czech) Naše Vojsko Publishers, Prague 1988.

    Google Scholar 

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Pilipčinec, E., Dorko, E., Tkáčiková, L. et al. The detection of anti-Candida antibodies on experimental animal models. Folia Microbiol 48, 555–558 (2003). https://doi.org/10.1007/BF02931340

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  • DOI: https://doi.org/10.1007/BF02931340

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