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Folia Microbiologica

, 50:19 | Cite as

Generation of landomycin D-producing strainStreptomyces globisporus LD3

  • B. Ostash
  • I. Kozarevska
  • V. Fedorenko
Article

Abstract

Rhodinosyl transferase geneIndGT4, governing the conversion of the disaccharide oligoketide (‘polyketide’) landomycin D into a trisaccharide derivative landomycin E, was deleted inStreptomyces globisporus 1912 genome. Possible resistance mechanisms that protect the resulting landomycin D-producing mutant strainS. globisporus LD3 against the toxic action of landomycins were determined.

Keywords

Streptomyces Polyketide Apramycin Mithramycin Landomycin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic 2005

Authors and Affiliations

  • B. Ostash
    • 1
  • I. Kozarevska
    • 1
  • V. Fedorenko
    • 1
  1. 1.Department of Genetics and BiotechnologyIvan Franko National University of LvivLvivUkraine

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