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Folia Microbiologica

, 48:51 | Cite as

Simple synthesis of novel diphenylsulfapyrimidine acetates from chalcones and their antimicrobial activity

  • A. A. F. Wasfy
  • A. A. Aly
Article

Abstract

Given the significant low yield (19–43 %) in reported results on the cyclocondensation of sulfaguanidine acetate with chalcones, a careful reinvestigation was carried out. A new series of chalcones, bearing electron-attracting groups in the aromatic moiety, have been used as precursors in the synthesis of diphenylsulfapyrimidine acetates with good yield. All synthesized compounds were active against G+- and G-bacteria, and fungi. Combination of substituents (Cl, OMe, NO2,etc.) enhanced antimicrobial activity. Derivative with two NO2 groups exhibits an activity comparable with sulfadiazine.

Keywords

Antimicrobial Activity Chalcones Acetamide Sulfadiazine Aromatic Moiety 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic 2003

Authors and Affiliations

  • A. A. F. Wasfy
    • 1
  • A. A. Aly
    • 1
  1. 1.Chemistry Department, Faculty of ScienceBenha UniversityBenhaEgypt

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