Folia Microbiologica

, 48:51 | Cite as

Simple synthesis of novel diphenylsulfapyrimidine acetates from chalcones and their antimicrobial activity

  • A. A. F. Wasfy
  • A. A. Aly


Given the significant low yield (19–43 %) in reported results on the cyclocondensation of sulfaguanidine acetate with chalcones, a careful reinvestigation was carried out. A new series of chalcones, bearing electron-attracting groups in the aromatic moiety, have been used as precursors in the synthesis of diphenylsulfapyrimidine acetates with good yield. All synthesized compounds were active against G+- and G-bacteria, and fungi. Combination of substituents (Cl, OMe, NO2,etc.) enhanced antimicrobial activity. Derivative with two NO2 groups exhibits an activity comparable with sulfadiazine.


Antimicrobial Activity Chalcones Acetamide Sulfadiazine Aromatic Moiety 
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Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic 2003

Authors and Affiliations

  • A. A. F. Wasfy
    • 1
  • A. A. Aly
    • 1
  1. 1.Chemistry Department, Faculty of ScienceBenha UniversityBenhaEgypt

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