Folia Microbiologica

, 33:466 | Cite as

Streptomycin and N-Methyl-N’-nitro-N-nitroso-guanidine inhibit incorporation of14C-precursors of macromolecule synthesis inEuglena gracillis

  • M. Mačor


Streptomycin and N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) cause a 100% hereditary bleaching ofEuglena gracilis. In spite of the outcomes being the same, the corresponding mechanisms differ. By investigating the incorporation of the14C-labelled precursors of macromolecule synthesis we showed streptomycin to inhibit the synthesis of nucleic acids and proteins to the same extent (56%), whereas in the case of MNNG a 66% inhibition of nucleic acid synthesis and a 24% one of protein synthesis were observed.


Nucleic Acid Synthesis Nitrosoguanidine Dihydrostreptomycin Macromolecule Synthesis Autotrophic Flagellate 
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Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic 1988

Authors and Affiliations

  • M. Mačor
    • 1
  1. 1.Institute of Biochemistry and BiotechnologyComenius UniversityBratislavaCzechoslovakia

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