The value of α-amylase and isoamylase determination in chronic renal failure patients
- 13 Downloads
Hyperamylasemia is a common finding in chronic renal failure (CRF) patients. It has been suggested that the diagnosis of acute pancreatitis in these patients is confirmed when serum amylase activities are greater than three times the upper normal limits. In order to evaluate the frequency, the type, and the hyperamylasemia levels in patients with various degree of chronic renal failure, the total serum amylase (Ta), the pancreatic (Pa) and salivary (Sa) types of serum isoamylases, as well as the urine isoamylases (Tu, Pu, Su, respectively) have been determined by the Phadebas method. Moreover, the levels of serum electrolytes and triglycerides were determined in order to study any relationship between serum electrolytes as well as triglycerides and aamylase activities. We studied 102 patients of whom 33 (group A) had CRF with serum creatinine levels 8.5 ±3.1 mg/dL (x± SD), 59 (group B) were receiving chronic hemodialysis, and 10 (group C) were on continuous ambulatory peritoneal dialysis as well as 47 normal individuals. None of the subjects studied had any clinical manifestation of acute pancreatitis. Our results showed that the Ta, Pa, and Sa levels of groups A, B, and C were significantly elevated compared to normal subjects. Eighteen patients had Pa activities greater than three times the upper normal limits. In the present study, no relationship between serum electrolytes as well as triglycerides and α-amylases was found. In conclusion, hyperamylasemia was a much more common finding in CRF patients than previously reported in the literature. We therefore feel that a definite diagnosis of acute pancreatitis in patients with CRF cannot be established by obtaining a value of serum α-amylase greater than threefold above the upper limit, of the normal range.
Key WordsHyperamylasemia isoamylases chronic renal failure
- 10.Blouhoff R, Tolleshaug H, Berg T. Binding of calcium ions to the isolated asialo-glycoprotein receptor. Implication for receptor function in suspended hepatocytes.J Biol Chem 1982; 257; 7456–7459.Google Scholar
- 11.Gross JB, Parkin TW, Maher FT, Power MH. Serum amylase and lipase values in renal and extrarenal azotemia.Gastroenterology 1960; 39: 79–82.Google Scholar
- 13.Morton WJ, Tedesco FJ, Harter HR, Alpers DH. Serum amylase determinations and amylase to creatinine clearance ratios in patients with chronic renal insufficiency.Gastroenterology 1976; 71: 594–598.Google Scholar
- 16.Levitt MD, Eckfeldt JH. Diagnosis of acute pancreatitis, inThe Exocrine Pancreas. Biology, Pathobiology and Diseases, Go VLW, Gardner JD, Brooks FP, Lebenthal E, DiMagno EP, Scheele GA. New York, Raven, 1986; 481–502.Google Scholar