Protective effect of nafamostat mesilate
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This in vivo and in vitro study demonstrates the protective effects of a new synthetic protease inhibitornafamostat mesilate, FUT-175—on increased cellular and lysosomal fragility within acinar cells during the early stage of cerulein-induced acute pancreatitis in rats. FUT-175 prevented hyperamylasemia, pancreatic edema, congestion owing to amylase, and lactic dehydrogenase (LDH) discharge from acini as well as cathepsin-B leakage from lysosomes dose-dependently in doses of 1-10 mg/kg h. These results suggest that FUT-175 can protect against pancreatitis at subcellular levels in lysosomes and cellular or organelle membranes. Proteases may well play the important role in the pathogenesis of acute pancreatitis, and such a low molecular protease inhibitor may be useful clinically in the treatment of acute pancreatitis.
Key WordsCerulein-induced pancreatitis cathepsin-B lactic dehydrogenase (LDH) nafamostat mesilate (FUT-175)
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