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International Journal of Pancreatology

, Volume 7, Issue 4, pp 325–330 | Cite as

Effect of proglucagon-derived peptides on amylase release from rat pancreatic acini

  • Volkmar Weber
  • Hans- Christoph Fehmann
  • Rüdiger Göke
  • Burkhard Göke
Article
  • 19 Downloads

Summary

The present study examined systematically the effect of proglucagon-derived peptides on secretion of the exocrine rat pancreas. It was studied whether glucagon, oxyntomodulin, glucagon (19–29), glucagon (22–29), glucagon-like peptide 1 (7–36)amide, or glucagon-like peptide 2(1, 10, 100, 1000 pM, respectively) alters basal or cholecystokinin-8 (1, 10, 100 pM)-induced amylase release from isolated acini. None of the peptides showed any effect on basal or CCK-stimulated amylase secretion. Furthermore, binding studies utilizing labeled peptides excluded specific binding sites on rat acinar cells for glucagon or glucagon-like peptide 1 (7-36) amide. Our data argue against a direct role for proglucagon-derived peptides in the regulation of exocrine pancreatic secretion in rats.

Key Words

Proglucagon oxyntomodulin glucagon glucagon-like peptide 1 & 2 glucagon 22–29 isolated pancreatic acini rat amylase secretion 

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Copyright information

© Humana Press Inc. 1990

Authors and Affiliations

  • Volkmar Weber
    • 1
  • Hans- Christoph Fehmann
    • 2
  • Rüdiger Göke
    • 1
  • Burkhard Göke
    • 3
  1. 1.Department of Internai MedicinePhillips University of MarburgMarburgFRG
  2. 2.Laboratory of Molecular Endocrinology, Massachusetts General HospitalHarvard Medical SchoolBoston
  3. 3.Department of PhysiologyUniversity of Michigan Medical SchoolAnn Arbor

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