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Folia Microbiologica

, Volume 30, Issue 3, pp 184–190 | Cite as

The function and origin of follicular dendritic cells

  • J. H. Humphrey
Article
  • 45 Downloads

Abstract

Follicular dendritic cells (dendritic reticular cells) in germinal centres bind antigen - antibody complexesvia C3 receptors and retain the complexes at their surface for long periods of time. The follicular dendritic cells (FDC) are distinct from macrophages and from dendritic cells found in T-dependent areas, and are not derived from bone marrow stem cells. On histological evidence it has been proposed that they are derived from reticulum cells. Complexes are probably transported to FDC by a subpopulation of B cells in the marginal zone. Binding of complexes to FDC causes germinal centre enlargement and is a very efficient, and possibly essential stimulus to the generation of B memory cells which recognize epitopes on antigen or antibody in the complexes. An hypothesis is discussed which draws together these observations and suggests that antigen on FDC plays a central role in control of humoral immunity.

Keywords

Memory Cell Germinal Centre Marginal Zone Reticulum Cell Follicular Dendritic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Brown J.C., Harris G., Papamichail M., Sljicic V.S., Holborow E.J.: The localization of aggregated human γ-globulin in the spleens of normal mice.Immunology 24, 955 (1973).PubMedGoogle Scholar
  2. CoICo R.F., Bhogal B.S., Thorbecke G.J.: Relationship of germinal centres in lymphoid tissue to immunologic memory. VI. Transfer of B-cell memory with lymph node cells fractionated according to their receptors for peanut agglutinin.J. Immunol. 131, 2254 (1983).PubMedGoogle Scholar
  3. Diener E., Ealy E.H.M., Legge J.: Phylogenetic studies on the immune response. III. Autoradiographie studies on the lymphoid system of the Australian echidnaTachyglossus aculeatus. Immunology 13, 339 (1967).Google Scholar
  4. Enriquez-Rincon F., Andrews E., Parkhouse R.M.E., Klaus G.G.B.: Suppression of follicular trapping of antigen-antibody complexes in mice treated with anti-IgM or anti-IgD antibodies from birth.Immunology 53, 713 (1984).PubMedGoogle Scholar
  5. Gerdes J.,Stein H., Mason D.Y.,Ziegler A.: Human dendritic reticulum cell of lymphoid follicles: Their antigenie profile and their identification as multinucleated giant cells.Virckow’s Arch. (Cell. Pathol.) 42, 161 (1983).Google Scholar
  6. Gray D., McConnell I., Kumaratne D., MacLennan I C.M., Humprey J.H., Bazin H.: Marginal zone B cells express CRI and CR2 receptors.Eur. J. Immunol. 14, 47 (1984).PubMedCrossRefGoogle Scholar
  7. Heinen E., Lilet-Leclerq C., Mason D.Y., Stein H., Boniver J., Radoux D., Kinet-Denoel C., Sinar L.J.: Isolation of follicular dendritic cells from human tonsils. II. Immunocyto-chemical characterization.Eur. J. Immunol. 14, 267 (1984).PubMedCrossRefGoogle Scholar
  8. HosaWaka T., Tanaka Y., Aoike A., Kawai K., Maramutsu S.: Studies in B-cell memory. III. T-dependent aspect of B memory generation in mice immunized with T-independent type 2 antigen.Immunology 53, 97 (1984).Google Scholar
  9. Humprey J.H.: The still unsolved germinal centre mystery, inImmune Reactivity of Lymphocytes (M. Feldman, A. Globerson, eds.).Adv. Exp. Biol. Med. 66, 711 (1976).Google Scholar
  10. Humphrey J.H., Grennan D.: Isolation and properties of spleen follicular dendritic cells, p. 823 in In VivoImmunology (P. Nieuwenhuis, A. A. van den Broek, eds.). Plenum Press, New York 1982.Google Scholar
  11. Humphrey J.H., Greenan D., Sundaram V.: The origin of follicular dendritic cells in the mouse and the mechanism of trapping immune complexes on them.Eur. J. Immunol. 14, 859 (1984).PubMedCrossRefGoogle Scholar
  12. Kamperdijk E.W.A., Raaymakers E.M., DeLeelw J.H.S., Hoefsmit E.J.W.: Lymph node macrophage and reticulum cells in the immune response. I. The primary response to paratyphoid vaccine.Cell Tissue Res. 192, 1 (1978).PubMedCrossRefGoogle Scholar
  13. Klaus G.G.B.: Antigen-antibody complexes elicit anti-idiotypic antibodies to self-idiotypes.Nature 272, 265 (1978).PubMedCrossRefGoogle Scholar
  14. Klaus G.G.B., Humphrey J.H., Kunkl A., Dongworth D.W.: The follicular dendritic cell: Its role in antigen presentation in the generation of immunologieal memory.Immunol. Rev. 53, 3 (1980).PubMedCrossRefGoogle Scholar
  15. MaoLennan I.C.M., Gray D., Kumaratne D.S., Bazin H.: The lymphocytes of splenic marginal zones: a distinct B-cell lineage.Immunol. Today 3, 305 (1982).CrossRefGoogle Scholar
  16. Malasit P., Humphrey J.H.: Molecular composition of complement-solubilized complexes and their fatein vivo. Immunology 48, 779 (1983).Google Scholar
  17. Mandel T.E., Phipps R.P., Abbot A., Tew J.G.: The follicular dendritic cell: Long term antigen retention during immunity.Immunol. Rev. 53, 29 (1980).PubMedCrossRefGoogle Scholar
  18. Nossal G.J.V., Ada G.L.:Antigens, Lymphoid Cells and the Immune Response. Academic Press, New York-London 1971.Google Scholar
  19. Nussenzweig M.C., Steinman R.M.: The cell surface of mouse lymphoid dendritic cells.Immunol. Today 3, 65 (1982).CrossRefGoogle Scholar
  20. Pryjma J., Humphrey J.H.: Prolonged C3 depletion by cobra venom factor in T-deprived mice and its implication for the role of C3 as an essential second signal for B cell triggerin.Immunology 28, 569 (1975).PubMedGoogle Scholar
  21. Radoux D.: La cellule folliculaire dendritique: Structure et fonctions dans les reactions immunitaires humorales.Thesis, University of Liege 1984.Google Scholar
  22. Rose M.L., Birback M.S.C., Wallis V.J., Forrester J.A., Davies A.J.S.: Peanut lectin binding properties of germinal centres in mouse lymphoid tissue.Nature 284, 364 (1980).PubMedCrossRefGoogle Scholar
  23. Steinman R.M., Cohn Z.A.: Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation tissue distribution.J. Exp. Med. 137, 1142 (1973).PubMedCrossRefGoogle Scholar
  24. Steinman R.M., Cohn Z.A.: Identification of a novel cell type in peripheral lymphoid organs of mice. II. Functional propertiesin vitro. J. Exp. Med. 139, 380 (1974).CrossRefGoogle Scholar
  25. Szakal A.K., Gieringer R.L., Kosco M.H., Tew J.G.: Isolated follicular dendritic cells: Cytochemical antigen localization, Nomarski, SEM and TEM morphologyJ. Immunol. 134, 1349 (1985).PubMedGoogle Scholar
  26. Veerman A.J.P.: On the interdigitating cells in the thymus-dependent areas of the rat spleen: a relation between the mononuclear phagocyte system and T-lymphocytes.Cell Tissue Res. 48, 247 (1974).Google Scholar
  27. White R.G., inThe Immunology Competent Cell (G. W. Wolstenholme, Knight, eds). Ciba Foundation Study Group No. 16. Churchill, London 1963.Google Scholar

Copyright information

© Institute of Microbiology, Academy of Sciences of the Czech Republic 1985

Authors and Affiliations

  • J. H. Humphrey
    • 1
  1. 1.Royal Postgraduate Medical SchoolHammersmith HospitalLondonEngland

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