Endocrine Pathology

, 5:66 | Cite as

Proopiomelanocortin mrna expression by small cell bladder carcinoma associated with cushing’s syndrome: diagnostic contribution of in situ hybridization

  • Elli Lakka-Papadodima
  • Yvonne Dimoula
  • George Kontogeorgos
  • Zissoula Manika
  • John Kiayias
  • Harafambos Theodorou
Case Report


A case of ectopic ACTH secretion by primary small-cell carcinoma of the urinary bladder is described. The patient, a 38-year-old woman, presented with Cushing's syndrome. Although immunocytochemistry of the tumor for ACTH and corticotropin-releasing factor yielded negative results, in situ hybridization demonstrated a conclusive signal for proopiomelanocortin messenger RNA. This case report shows the value of in situ hybridization in diagnostic pathology.


Endocrine Pathology Volume Clear Cell Sarcoma POMC mRNA Ectopic ACTH Syndrome Ectopic ACTH Secretion 


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Copyright information

© Humana Press Inc. 1994

Authors and Affiliations

  • Elli Lakka-Papadodima
    • 1
    • 2
  • Yvonne Dimoula
    • 1
    • 2
  • George Kontogeorgos
    • 1
    • 2
  • Zissoula Manika
    • 1
    • 2
  • John Kiayias
    • 1
    • 2
  • Harafambos Theodorou
    • 1
    • 2
  1. 1.Departments of Clinical Endocrinology and Urology“Polyklinic” Hospital of AthensAthensGreece
  2. 2.Department of PathologyGeneral Hospital of AthensGreece

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