Endocrine Pathology

, Volume 3, Issue 1, pp 47–51 | Cite as

Silent corticotroph adenoma with multiple cysts: Pars intermedia tumor?

  • Hiroshi Nishioka
  • Asao Hirano
  • Sylvia L. Asa
Case Report


A silent corticotroph adenoma with multiple cysts was found incidentally at autopsy. By immunohistochemistry, most of the adenoma cells contained reactivity for adrenocorticotropic hormone and beta-endorphin; a few cells stained for beta-subunit of luteinizing hormone. The cysts, interspersed within the tumor, were lined by cuboidal epithelium with foci of stratified squamous epithelium. The lining cells contained immunoreactive keratin; some cells were positive for S-100 protein or glial fibrillary acidic protein, and a few cells were also immuno-stained for adrenocorticotropic hormone and beta-endorphin. It is suggested that this tumor may represent a neoplasm of pars intermedia derivation.


Adenoma Luteinizing Hormone Pituitary Adenoma Adenoma Cell Anterior Lobe 
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Copyright information

© Humana Press Inc. 1992

Authors and Affiliations

  • Hiroshi Nishioka
    • 1
  • Asao Hirano
    • 1
  • Sylvia L. Asa
    • 2
  1. 1.Bluestone Laboratory, Division of Neuropathology, Department of PathologyMontefiore Medical CenterBronx
  2. 2.Department of Pathology, St. Michael’s HospitalUniversity of TorontoTorontoCanada

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