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Immunologic Research

, Volume 10, Issue 3–4, pp 423–427 | Cite as

Functions of interleukin-4 on human B lymphocytes

  • Jacques Banchereau
  • Françoise Rousset
B Cell Differentiation

Conclusions

In vitro studies have demonstrated that IL-4 can either enhance or inhibit the proliferation of human B cells depending on their mode of activation and the nature of the calls and/or cytokines in the immediate environment. Of these in vitro effects, it is now clear from in vivo studies in mice, that IL-4 plays a key role in the production of IgE [15]. It is, however, not yet determined whether IL-4 plays any role in vivo in the antigen-dependent clonal expansion of B cells. Our demonstration of the crucial role of cross-linking of the CD40 antigen in the proliferation and differentiation of human B lymphocytes leads us to question the role of this antigen. Recent studies have demonstrated this antigen to be homologous to the nerve growth factor receptor [16] and the two receptors for TNF [17–19]. It is therefore tempting to speculate that the CD40 antigen may either be the receptor for a cytokine or the ligand for a membrane counterstructure expressed on cells interacting with B cells.

Keywords

Nerve Growth Factor Receptor Recombinant Cytokine Staphylococcus Aureus Cowan Day2 Day7 Mononuclear Cell System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Paul WE, Ohara J: B-cell stimulatory factor-1 interleukin 4. Annu Rev Immunol 1987;5:429–459.PubMedGoogle Scholar
  2. 2.
    Yokota T, Arai N, de Vries JE, Spits H, Banchereau J, Zlotnick A, Rennick D, Howard M, Takebe Y, Miyatake S, Lee F, Arai KI: Molecular biology of interleukin-4 and interleukin-5 genes and biology of their products that stimulate B cells, T cells and hemopoietic cells. Immunol Rev 1988;102:137–187.PubMedCrossRefGoogle Scholar
  3. 3.
    Banchereau J: Interleukin 4; in Thomson AW (ed): Immunology and Molecular Biology of Cytokines. London, Academic Press, in press.Google Scholar
  4. 4.
    Defrance T, Vanbervliet B, Aubry JP, Takebe Y, Arai N, Miyajima A, Yokota T, Lee T, Arai K, de Vries JE, Banchereau J: B cell growth promoting activity of recombinant human IL-4. J Immunol 1987;139:1135–1141.PubMedGoogle Scholar
  5. 5.
    Defrance T, Vanbervliet B, Aubry JP, Banchereau J: Interleukin-4 inhibits the proliferation but not the differentiation of activated human B cells in response to interleukin-2. J Exp Med 1988;168:1321–1337.PubMedCrossRefGoogle Scholar
  6. 6.
    Karray S, Defrance T, Merle-Béral H, Banchereau J, Debré P, Galanaud P: Interleukin-4 counteracts the interleukin-2-induced proliferation of monoclonal B cells. J Exp Med 1988;168:85–94.PubMedCrossRefGoogle Scholar
  7. 7.
    Vallé A, Zuber CE, Defrance T, Djossou O, De Rie M, Banchereau J: Activation of human B lymphocytes through CD40 and interleukin-4. Eur J Immunol 1989;19:1463–1467.PubMedCrossRefGoogle Scholar
  8. 8.
    Gordon J, Millsum MJ, Guy GR, Ledbetter JA: Resting B lymphocytes can be triggered directly through the CDw40 (Bp50) antigen. J Immunol 1988;140:1425–1430.PubMedGoogle Scholar
  9. 9.
    Banchereau J, de Paoli P, Vallé A, Garcia E, Rousset F: Long-term human B cell lines dependent on interleukin 4 and anti CD40. Science 1991;251:70–72.PubMedCrossRefGoogle Scholar
  10. 10.
    Defrance T, Vanbervliet B, Pène J, Banchereau J: Human recombinant IL-4 induces activated B lymphocytes to produce IgG and IgM. J Immunol 1988;141:2000–2005.PubMedGoogle Scholar
  11. 11.
    Pène J, Rousset F, Brière F, Chrétien I, Bonnefoy JY, Spits H, Yokota T, Arai N, Arai KI, Banchereau J, De Vries JE: IgE production by normal human lymphocytes is induced by interleukin-4 and suppressed by interferons gamma and alpha and prostaglandin E2. Proc Natl Acad Sci USA 1988;85:6890–6884.CrossRefGoogle Scholar
  12. 12.
    Thyphoronitis G, Tsokos GC, June CH, Levine AD, Finkelman FD: IgE secretion by Epstein-Barr virus-infected purified human B lymphocytes is stimulated by interleukin-4 and suppressed by inteferon-γ. Proc Natl Acad Sci USA 1989;86:5580–5584.CrossRefGoogle Scholar
  13. 13.
    Llorente L, Crevon ML, Karray S, Defrance T, Banchereau J, Galanaud P: Interleukin (IL) 4 counteracts the helper effect of IL-2 on antigen-activated human B cells. Eur J Immunol 1989;19:765–769.PubMedCrossRefGoogle Scholar
  14. 14.
    Callard RE, Smith SH, Scott KE: The role of interleukin 4 (IL-4) in specific antibody responses by human B cells. Int Immunol 1991;3:157–163.PubMedCrossRefGoogle Scholar
  15. 15.
    Finkelman FD, Holmes J, Katona IM, Urban JF, Beckmann MP, Schooley KA, Coffman RL, Mosmann TR, Paul WE: Lymphokine control of in vivo immunoglobulin isotype selection. Annu Rev Immunol 1990;8:303–333.PubMedCrossRefGoogle Scholar
  16. 16.
    Stamenkovic I, Clark EA, Seed B: A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas. EMBO J 1989;8:1403–1410.PubMedGoogle Scholar
  17. 17.
    Loetscher H, Pan YCE, Lahm HW, Gentz R, Brockhaus M, Tabuchi H, Lesslauer W: Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor. Cell 1990;61:351–359.PubMedCrossRefGoogle Scholar
  18. 18.
    Schall TJ, Lewis M, Koller KJ, Lee A, Rice GC, Wong GHW, Gatanaga T, Granger GA, Lentz R, Raab H, Kohr WJ, Goeddel DV: Molecular cloning and expression of a receptor for human tumor necrosis factor. Cell 1990;61:361–370.PubMedCrossRefGoogle Scholar
  19. 19.
    Smith CA, Davis T, Anderson D, Sclam L, Beckmann MP, Jerzy R, Dower SK, Cosman D, Goodwin RG: A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins. Science 1990;248:1019–1022.PubMedCrossRefGoogle Scholar

Copyright information

© Humana Press Inc. 1991

Authors and Affiliations

  • Jacques Banchereau
    • 1
  • Françoise Rousset
    • 1
  1. 1.Schering-PloughLaboratory for Immunological ResearchDardilly Cedex(France)

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