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Immunologic Research

, Volume 10, Issue 3–4, pp 404–406 | Cite as

A cautionary note concerning the possibility that transforming growth factor-beta is a switch factor that acts on primary B cells to initiate IgA expression

  • John J. Cebra
  • Anna George
  • Roy L. Kerlin
B Cell Differentiation

Keywords

Isotype Switching Bulk Culture Switch Factor Limit Cell Outgrowth Isotype Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Snapper CM, Paul WE: B cell stimulatory factor-1 (interleukin 4) prepares resting murine B cells to secrete IgG1 upon subsequent stimulation with bacterial lipopolysaccharide. J Immunol 1987; 139:10–17.PubMedGoogle Scholar
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    Lebman DA, Coffman RL: Interleukin 4 causes isotype switching to IgE in T cell-stimulated clonal B cell cultures. J Exp Med 1988;168:853–862.PubMedCrossRefGoogle Scholar
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    Esser C, Radbruch A: Rapid induction of transcription of unrearranged sγ 1 switch regions in activated murine B cells by interleukin 4. EMBO J 1989;8:483–488.PubMedGoogle Scholar
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    Coffman RL, Lehman DA, Shrader B: Transforming growth factor-beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes. J Exp Med 1989;170:1039–1044.PubMedCrossRefGoogle Scholar
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    Schrader CE, George A, Kerlin RL, Cebra JJ: Dendritic cells support production of IgA and other non-IgM isotypes in clonal microculture. Int Immunol 1990;2:563–570.PubMedCrossRefGoogle Scholar
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    Kim P-Y, Kagnoff MF: Transforming growth factor β1 increases IgA isotype switching at the clonal level. J Immunol 1990;145:3773–3778.PubMedGoogle Scholar

Copyright information

© Humana Press Inc. 1991

Authors and Affiliations

  • John J. Cebra
    • 1
  • Anna George
    • 1
  • Roy L. Kerlin
    • 1
  1. 1.Department of BiologyUniversity of PennsylvaniaPhiladelphia(USA)

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