Immunologic Research

, Volume 10, Issue 3–4, pp 177–182 | Cite as

Regulation of the development of helper T cell subsets

  • Susan L. Swain
T Cell Subsets


Cell Subset Memory Cell Lymph Node Homing Stimulation Effector Cell Surface Marker Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Coffman RL, Seymour BWP, Lebman DA, Hiraki DD, Christiansen JA, Sharder BM, Cherwinski H, Savelkoul HFJ, Finkelman FD, Bond MW, Mosmann TR: The role of helper T cell products in mouse B cell differentiation and isotype regulation. Immunol Rev 1988;102:5–28.PubMedCrossRefGoogle Scholar
  2. 2.
    Swain SL, McKenzie DT, Dutton RW, Tonkonogy SL, English M: The role of IL4 and IL5: characterization of a distinct helper T cell subset that makes IL4 and IL5 (Th2) and requires priming before induction of lymphokine secretion. Immunol Rev 1988;102:77–105.PubMedCrossRefGoogle Scholar
  3. 3.
    Swain, SL, McKenzie DT, Weinberg AD, Hancock W: Characterization of T helper 1 and 2 cell subsets in normal mice. Helper T cells reponsible for IL-4 and IL-5 production are present as precursors that require priming before they develop into lymphokine-secreting cells. J Immunol 1988; 141:3445–3455.PubMedGoogle Scholar
  4. 4.
    Swain, SL, Weinberg AD, English M: CD4+ T cell subsets: Lymphokine secretion of memory cells and of effector cells which develop from precursors in vitro. J Immunol 1990;144:1788–1799.PubMedGoogle Scholar
  5. 5.
    Swain, SL, Weinberg AD, English M, Huston G: IL-4 directs the development of Th2-like helper effectors. J Immunol 1990;145:3796–3806.PubMedGoogle Scholar
  6. 6.
    Bradley LM, Duncan DD, Swain SL: Induction of antigen-specific CD4+ lymphokine secreting effector cells in vivo. Fed Proc. 1990;4:206.Google Scholar
  7. 7.
    Weinberg AD, English ME, Swain SL: Distinct regulation of lymphokine production is found in fresh versus in vitro primed murine helper cells. J Immunol 1990;144:1800–1807.PubMedGoogle Scholar
  8. 8.
    LeGros G, Ben-Sasson SZ, Seder R, Finkeman FD, Paul WE: Generation of interleukin 4 (IL-4) producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4 producing cells. J Exp Med 1990;172:921–929.CrossRefGoogle Scholar
  9. 9.
    Locksley RM, Heinzel FP, Holaday BJ, Sandesh SM, Reiner SL, Sadick, MD: Induction of Th1 and Th2 CD4+ subsets during murine leishmania infection. Res Immunol, in press.Google Scholar
  10. 10.
    Swain SL, Weinberg AD, Huston G: IL-4 and IFN-γ direct the development of distinet subsets of helper T cells. Fed Proc 1990;4:2020.Google Scholar

Copyright information

© Humana Press Inc. 1991

Authors and Affiliations

  • Susan L. Swain
    • 1
    • 2
  1. 1.Department of BiologyUniversity of California, San DiegoLa Jolla(USA)
  2. 2.UCSD Cancer CenterUniversity of California, San DiegoLa Jolla(USA)

Personalised recommendations