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Survey of Immunologic Research

, Volume 4, Issue 2, pp 146–159 | Cite as

Exon shuffling: New genes from old

  • David H. Margulies
  • James McCluskey
Molecular Immunology

Keywords

Major Histocompatibility Complex Recombinant Gene Bluestone Exon Shuffling Transplantation Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Steinmetz, M.; Hood, L.: Genes of the major histocompatibility complex in mouse and man. Science222: 727–733 (1983).PubMedCrossRefGoogle Scholar
  2. 2.
    Evans, G.A.; Margulies, D.H.; Shykind, B.; Seidman, J.G.; Ozato, K..: Exon shuffling: mapping polymorphic determinants on hybrid mouse transplantation antigens. Nature, Lond.300: 755–757 (1982).CrossRefGoogle Scholar
  3. 3.
    Allen, H.; Wraith, D.; Pala, P.; Askonas, B.; Flavell, R.A.: Domain interactions of H-2 class I antigens alter cytotoxic T-cell recognition sites. Nature, Lond.309: 279–281 (1984).CrossRefGoogle Scholar
  4. 4.
    Arnold, B.; Burgert, H.-G.; Hamann, U.; Hammerling, G.; Kees, U.; Kvist, S.: Cytolytic T cells recognize the two amine-terminal domains of H-2 K antigens in tandem in influenza infected cells. Cell38: 79–87 (1984).PubMedCrossRefGoogle Scholar
  5. 5.
    Stroynowski, I.; Orn, A.; Goodenow, R.S.; McMillan, M.; Forman, J.; Brayton, P.R.; Frelinger, J.; Hood, L.: Cytotoxic T lymphocytes recognize determinants on the BALB/c-H-2Ld molecule controlled by αl and α2 but not α3 external domains. Immunogenetics20: 141–154 (1984).PubMedCrossRefGoogle Scholar
  6. 6.
    Zuniga, M.C.; Malissen, B.; McMillan, M.; Brayton, P.R.; Clark, S.S.; Forman, J.; Hood, L.: Expression and function of transplantation antigens with altered or deleted cytoplasmic domains. Cell34: 535–544 (1983).PubMedCrossRefGoogle Scholar
  7. 7.
    Murre, C; Choi, E.; Weis, J.; Seidman, J.G.; Ozato, K.; Liu, L.; Burakoff, S.J.; Reiss, C.S.: Dissection of serological and cytolytic T lymphocyte epitopes on murine major histocornpatibility antigens by a recombinant H-2 gene separating the first two external domains. J. exp. Med.160: 167–178 (1984).PubMedCrossRefGoogle Scholar
  8. 8.
    Murre, C; Reiss, C.J.; Bernabeu, C; Chen, L.B.; Burakoff, S.J.; Seidman, J.G.: Construction, expression and recognition of an H-2 molecule lacking its carboxyl terminus. Nature, Lond.307: 432–436 (1984).CrossRefGoogle Scholar
  9. 9.
    Jordan, B.R.; Lemonnier, F.A.; Caillol, D.H.; Trucy, J.: Transformation of murine LMTK- cells with purified HLA class I genes. III. Human HLA class I antigens coded by hybrid genes constructed in vitro indicate association of serologic reactivities with the first two domains of the molecule. Immunogenetics18: 165–171 (1983).PubMedCrossRefGoogle Scholar
  10. 10.
    Germain, R.N.; Ashwell, J.D.; Lechler, R.I.; Margulies, D.H.; Nickerson, K.M.; Suzuki, G.; Tou, J.Y.L.: Exon-shuffling maps control of antibody and T cell recognition sites to the NH2-terminal domain of Aβ. Proc. natn. Acad. Sci. USA (in press 1985).Google Scholar
  11. 11.
    McCluskey, J.; Germain, R.N.; Margulies, D.H.: Cell surface expression of an in vitro recombinant class II/class I major histocompatibility complex gene product. Cell40: 247–257 (1985).PubMedCrossRefGoogle Scholar
  12. 12.
    Shiroishi, T.; Evans, G.A.; Appeila, E.; Ozato, K.: Role of a disulfide bridge in the immune function of major histocompatibility class I antigen as studied by in vitro mutagenesis. Proc. natn. Acad. Sci. USA81: 7544–7548 (1984).CrossRefGoogle Scholar
  13. 13.
    Klein, J.: Biology of the mouse histocompatibility complex (Springer, Berlin 1975).Google Scholar
  14. 14.
    Snell, G.; Dausset, J.; Nathenson, S.G.: Histocompatibility (Academic Press, New York 1976).Google Scholar
  15. 15.
    Schwartz, R.S.: Functional properties of I region gene products and theories of immune response (Ir) gene function; in Femme, David, Ia Antigens. I. Mice, pp. 161–218 (CRC Press, Boca Raton 1982).Google Scholar
  16. 16.
    Coligan, J.E.; Kindt, T.J.; Uehara, H.; Martinko, J.; Nathenson, S.G.: Primary structure of a murine transplantation antigen. Nature, Lond.291: 35–39 (1981).CrossRefGoogle Scholar
  17. 17.
    Nathenson, S.G.; Uehara, H.; Ewenstein, B.; Kindt, T.J.; Coligan, J.E.: Primary structural analysis of the transplantation antigens of the murine H-2 major histocompatibility complex. A. Rev. Biochem.50: 1025–1052 (1981).CrossRefGoogle Scholar
  18. 18.
    Jones, P.P.: Analysis of H-2 and Ia molecules by two dimensional polyacrylamide gel electrophoresis. J. exp. Med.146: 1261–1272 (1977).PubMedCrossRefGoogle Scholar
  19. 19.
    Steinmetz, M.; Moore, K.V.; Frelinger, J.G.; Sher, B.T.; Shen, F.-W.; Boyse, E.A.; Hood, L.: A pseudogene homologous to mouse transplantation antigens: transplantation antigens are encoded by eight exons that correlate with protein domains. Cell25: 683–692 (1981).PubMedCrossRefGoogle Scholar
  20. 20.
    Evans, G.A.; Margulies, D.H.; Camerini-Otero, R.D.; Ozato, K.; Seidman, J.G.: Structure and expression of a mouse major histocompatibility antigen gene, H-2Ld. Proc. natn. Acad. Sci. USA79: 1994–1998 (1982).CrossRefGoogle Scholar
  21. 21.
    Kvist, S.; Roberts, L.; Dobberstein, B.: Mouse histocompatibility genes: structure and organisation of a Kd gene. EMBO J.2: 245–254 (1983).PubMedGoogle Scholar
  22. 22.
    Weiss, E.; Golden, L.; Zakut, R.; Mellor, A.; Fahmer, K.; Kvist, S.; Flavell, R.A.: The DNA sequence of the H-2Kb gene: evidence for gene conversion as a mechanism for the generation of polymorphism in histocompatibility antigens. EMBO J.2: 453–462 (1983).PubMedGoogle Scholar
  23. 23.
    Parnes, J.; Seidman, J.G.: Structure of wild-type and mutant mouse β2-microglobulin genes. Cell29: 661–669 (1982).PubMedCrossRefGoogle Scholar
  24. 24.
    Shackelford, D.A.; Kaufman, J.F.; Korman, A.J.; Strominger, J.L.: HLA-DR antigens: structure, separation of subpopulations, gene cloning and function. Immunol. Rev.66: 133–187 (1982).PubMedCrossRefGoogle Scholar
  25. 25.
    Choi, E.; Mclntyre, K.; Germain, R.N.; Seidman, J.G.: Murine I-A chain polymorphism: nucleotide sequences of three allelic I-Aβ; genes. Science221: 283–286 (1983).PubMedCrossRefGoogle Scholar
  26. 26.
    Malissen, M.; Hunkapiller, T.; Hood, L.: Nucleotide sequence of a light chain gene of the mouse I-A subregion: Aβ. Science221: 750–754 (1983).PubMedCrossRefGoogle Scholar
  27. 27.
    Hyldig-Nielsen, J.J.; Schenning, L.; Hammerling, U.; Widmark, E.; Heldin, E.; Lind, P.; Servenius, B.; Lund, T.; Flavell, R.; Lee, J.S.; Trowsdale, J.; Schreir, P.H.; Zablitsky, F.; Larhammar, D.; Peterson, P.A.; Rask, L.: The complete nucleotide sequence of the I-Ed α immune response gene. Nucl. Acids Res.11: 5055–5071 (1983).PubMedCrossRefGoogle Scholar
  28. 28.
    Mathis, D.J.; Benoist, C.O.; Williams, II, V.E.; Kanter, M.E.; McDevitt, H.O.: The murine Eα, immune response gene. Cell32: 745–754 (1983).PubMedCrossRefGoogle Scholar
  29. 29.
    Patten, P.; Yokota, T.; Rothbard, J.; Chien, Y.-H.; Arai, K.-L; Davis, M.M.: Structure, expression, and divergence of T-cell receptor β; chain variable regions. Nature, Lond.312: 40–46 (1984).CrossRefGoogle Scholar
  30. 30.
    Bluestone, J.A.; Foo, M.; Allen, H.; Flavell, R.A.: Allospecific cytolytic T lymphocytes recognize conformational determinants on hybrid mouse transplantation antigens (submitted for publication, 1984).Google Scholar
  31. 31.
    Ozato, K.; Evans, G.A.; Shykind, B.; Margulies, D.H.; Seidman, J.G.: Hybrid H-2 histocompatibility gene products assign domains recognized by alloreactive T cells. Proc. natn. Acad. Sci. USA80: 2040–2043 (1983).CrossRefGoogle Scholar
  32. 32.
    Reiss, C.S.; Evans, G.A.; Margulies, D.H.; Seidman, J.G.; Burakoff, S.J.: Allospecific and virusspecific cytolytic T lymphocytes are restricted to the N or Cl domain of H-2 antigens expressed on L cells after DNA-mediated gene transfer. Proc. natn. Acad. Sci. USA50: 2709–2712 (1983).CrossRefGoogle Scholar
  33. 33.
    Malissen, B.; Peele-Price, M.; Goverman, J.M.; McMillan, M.; White, J.; Kappler, J.; Marrack, P.; Pierres, A.; Pierres, M.; Hood, L.: Gene transfer of H-2 class II genes: antigen presentation by mouse fibroblast and hamster B cell lines. Cell36: 319–327 (1984).PubMedCrossRefGoogle Scholar
  34. 34.
    Norcross, M.A.; Bentley, D.M.; Margulies, D.H.; Germain, R.N.: Membrane Ia expression and antigen-presenting accessory cell function of L cells transfected with class II MHC genes. J. exp. Med.160: 1316–1337 (1984).PubMedCrossRefGoogle Scholar
  35. 35.
    Gordon, J.W.; Scangos, G.A.; Plotkin, D.J.; Barbosa, J.A.; Ruddle, F.H.: Genetic transformation of mouse embryos by microinjection of purified DNA. Proc. natn. Acad. Sci. USA77: 7380–7384 (1980).CrossRefGoogle Scholar
  36. 36.
    Constantini, F.; Lacy, E.: Introduction of a rabbit β globin gene into the mouse germ line. Nature, Lond.294: 92–94 (1981).CrossRefGoogle Scholar

Copyright information

© Humana Press Inc. 1985

Authors and Affiliations

  • David H. Margulies
    • 1
  • James McCluskey
    • 1
  1. 1.Laboratory of Immunology, National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaUSA

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