Advertisement

Survey of Immunologic Research

, Volume 4, Issue 4, pp 297–302 | Cite as

MHC-Unrestricted cytolytic T lymphocytes

  • Alan M. Krensky
  • Carol Clayberger
Cellular Immunology

Keywords

Major Histocompatibility Complex Major Histocompatibility Complex Molecule Human Natural Killer Cell Cell Surface Structure Endothelial Cell Line Blood Vessel 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Doherty, P.C.; Blanden, R.V.; Zinkernagel, R.M.: Specificity of virus-immune effector T cells for H- 2K or H-2D compatible interactions: implications for H-antigen diversity. Transplant. Rev.29: 89–124 (1976).PubMedGoogle Scholar
  2. 2.
    Zinkernagel, R.M.; Doherty, P.C.: H-2 compatibility requirement for T cell mediated lysis of targets infected with lymphocytic choriomeningitis virus. Different cytotoxic T cell specificities are associated with structures coded in H-2K or H-2I. J. exp. Med.141: 1427–1436 (1975).PubMedCrossRefGoogle Scholar
  3. 3.
    Lanier, L.L.; Le, A.M.; Phillips, J.H.; Warner, N.L.; Babcock, G.F.: Subpopulations of human natural killer cells defined by expression of the Leu-7 (HNK-1) and Leu-11 (NK-15) antigens. J. Immun.131: 1789–1796 (1983).PubMedGoogle Scholar
  4. 4.
    Perussia, B.; Starr, S.; Abraham, S.; Fanning, V.; Trinchieri, G.: Human natural killer cells analyzed by B73.1, monoclonal antibody blocking Fc receptor functions. I. Characterization of the lymphocyte subset reactive with B73.1. J. Immun.130: 2133–2141 (1983).PubMedGoogle Scholar
  5. 5.
    Rumpold, H.; Kraft, D.; Obexer, G.; Bock, G.; Gebhart, W.: A monoclonal antibody against a surface antigen shared by human large granular lymphocytes. J. Immun.129: 1458–1464 (1982).PubMedGoogle Scholar
  6. 6.
    Ritz, J.; Campen, T.J.; Schmidt, R.E.; Royer, H.D.; Hercend, T.; Hussey, R.E.; Reinherz, EL.: Analysis of T cell receptor gene rearrangement and expression in human natural killer clones. Science228: 1540–1543 (1985).PubMedCrossRefGoogle Scholar
  7. 7.
    Perussia, B.; Trinchieri, G.; Jackson, A.; Warner, N.L.; Faust, J.; Rumpold, H.; Kraft, D.; Lanier, L.L.: The Fc receptor for IgG on human natural killer cells: phenotypic, functional, and comparative studies with monoclonal antibodies. J. Immun.133: 180–189 (1984).PubMedGoogle Scholar
  8. 8.
    Grimm, E.A.; Mazumder, A.; Zhang, H.Z.; Rosenberg, S.A.: The lymphokine activated killer cell phenomenon: lysis of NK resistant fresh solid tumor cells by IL-2 activated autologous human peripheral blood lymphocytes. J. exp. Med.155: 1823–1841 (1982).PubMedCrossRefGoogle Scholar
  9. 9.
    Grimm, E.A.; Robb, R.J.; Roth, J.A.; Neckers, L.M.; Lackman, L.; Wilson, DJ.; Rosenberg, S.A.: Lymphokine activated killer cell phenomenon. III. Evidence that IL-2 alone is sufficient for direct activation of PBL into LAK. J. exp. Med.158: 1356–1361 (1983).PubMedCrossRefGoogle Scholar
  10. 10.
    Ballas, Z.K.; Ahmann, G.B.: Generation of cytotoxic T lymphocytes against modified self in the absence of antigen by interleukin-2 containing preparations. Cell. Immunol.76: 81–93 (1983).PubMedCrossRefGoogle Scholar
  11. 11.
    Mazumder, A.; Rosenberg, S.A.: Successful immunotherapy of natural killer-resistant established pulmonary melanoma metastases by the intravenous adoptive transfer of syngeneic lymphocytes activated in vitro by interleukin 2. J. exp. Med.159: 495–507 (1984).PubMedCrossRefGoogle Scholar
  12. 12.
    Rosenberg, S.A.; Lotz, M.P.; Muul, L.M.; Leitman, S.; Chang, A.E.; Ettinghausen, S.E.; Matory, Y.L.; Skibber, J.M.; Shiloni, E.; Vetto, J.J.; Seipp, C.A.; Simpson, C.; Reichert, C.M.: Observation on the systemic administration of autologous lymphokine activated killer cells and recombinant interleukin 2 to patients with metastatic cancer. New Engl. J. Med.313: 1485–1492 (1985).PubMedGoogle Scholar
  13. 13.
    Brooks, C.G.; Urdal, D.L.; Henney, C.S.: Lymphokinedriven differentiation of cytotoxic T cell clones into cells with NK-like specificity: correlations with display of membrane macromolecules. Immunol. Rev.72: 43–72 (1983).PubMedCrossRefGoogle Scholar
  14. 14.
    Shortman, K.; Wilson, A.; Scollay, R.; Chen, W.F.: Development of large granular lymphocytes with anomalous, nonspecific cytotoxicity in clones derived from Ly-2+ T cells. Proc. natn. Acad. Sci. USA80: 2728–2732 (1983).CrossRefGoogle Scholar
  15. 15.
    Burus, G.F.; Triglia, T.; Werkmeister, J.A.: In vitro generation of human activated lymphocyte killer cells: separate precursors and modes of generation of NK-like cells and ‘anomalous’ killer cells. J. Immun.133: 1656–1663 (1984).Google Scholar
  16. 16.
    Krensky, A.M.; Clayberger, C.: Diagnostic and therapeutic implications of T cell surface antigens. Transplantation39: 339–348 (1985).PubMedCrossRefGoogle Scholar
  17. 17.
    Vries, J.E. de; Spits, H.: Cloned human cytotoxic T lymphocyte (CTL) lines reactive with autologous melanoma cells. I. In vitro generation, isolation, and analysis to phenotype and specificity. J. Immun.132: 510–519 (1984).PubMedGoogle Scholar
  18. 18.
    Yssel, H.; Spits, H.; Vries, J.E. de: A cloned human T cell line cytotoxic for autologous and allogeneic B lymphoma cells. J. exp. Med.160: 239–254 (1984).PubMedCrossRefGoogle Scholar
  19. 19.
    Clayberger, C.; Uyehara, T.; Hardy, B.; Eaton, J.; Karasek, M.; Krensky, A.M.: Target specificity and cell surface structures involved in the human cytolytic T lymphocyte response to endothelial cells. J. Immun.135: 12–18 (1985).PubMedGoogle Scholar
  20. 20.
    Clayberger, C.; Koller, T.D.; Carroll, W.; Link, M.; Smith, S.D.; Levy, R.; Krensky, A.M.: Idiotype specific lysis of B cell tumor by autologous human cytolytic T lymphocytes (submitted, 1986).Google Scholar
  21. 21.
    Moretta, A.; Pantaleo, G.; Mingari, M.D.; Moretta, L.: Cerottini, J.C.: Clonal heterogeneity in the requirement for T3, T4, and T8 molecules in human cytolytic T lymphocyte function. J. exp. Med.159: 921–934 (1984).PubMedCrossRefGoogle Scholar

Copyright information

© Humana Press Inc. 1985

Authors and Affiliations

  • Alan M. Krensky
    • 1
  • Carol Clayberger
    • 1
  1. 1.Department of PediatricsStanford University Medical CenterCalif.(USA)

Personalised recommendations