Survey of Immunologic Research

, Volume 4, Issue 1, pp 6–10 | Cite as

The prothymocyte: Cellular and molecular biology

  • Edward A. Boyse
Cellular Immunology, Symposium


Spleen Cell Surface Phenotype Complete Amino Acid Sequence Thymic Hormone Thymic Pathology 
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  1. 1.
    Komuro, K.; Boyse, E.A.; Old, L.J.: Production of TL antibody by mice immunized with TL-cell populations: a possible assay fro thymic hormone. J. exp. Med.137: 533–536 (1973).PubMedCrossRefGoogle Scholar
  2. 2.
    Komuro, K.; Boyse, E.A.: In vitro demonstration of thymic hormone in the mouse by conversion of precursor cells into lymphocytes. Lanceti: 740–743(1973).CrossRefGoogle Scholar
  3. 3.
    Komuro, K.; Boyse, E.A.: Induction of T lymphocytes from precursor cells in vitro by a product of the thymus. J. exp. Med.138: 479–482 (1973).PubMedCrossRefGoogle Scholar
  4. 4.
    Scheid, M.P.; Hoffmann, M.K.; Komuro, K.; Hammerling, U.; Abbott, J.; Boyse, E.A.; Cohen, G.H.; Hooper, J.A.; Schulof, R.S.; Goldstein, A.L.: Differentiation of T cells induced by preparations from thymus and non-thymic agents. J. exp. Med.138: 1027–1032(1973).PubMedCrossRefGoogle Scholar
  5. 5.
    Goldstein, G.: Isolation of a bovine thymin: a polypeptide hormone of the thymus. Nature, Lond.247: 11 (1974).CrossRefGoogle Scholar
  6. 6.
    Goldstein, G.; Scheid, M.P.; Hammerling, U.; Boyse, E.A.; Schlesinger, D.H.; Niall, H.D.: Isolation of a polypeptide which has lymphocyte-differentiating properties and is probably represented universally in living cells. Proc. natn. Acad. Sci.72: 11–15(1975).CrossRefGoogle Scholar
  7. 7.
    Schlesinger, D.H.; Goldstein, G.: The amino acid sequence of thymopoietin. II. Cell5: 361 (1975).PubMedCrossRefGoogle Scholar
  8. 8.
    Audhya, T.; Schlesinger, D.H.; Goldstein, G.: Complete amino acid sequences of bovine thymopoietins I, II, and III: closely homologous polypeptides. Biochemistry20: 6195–6200 (1981).PubMedCrossRefGoogle Scholar
  9. 9.
    Schlesinger, D.H.; Goldstein, G.; Niall, H.D.: The complete amino acid sequence of ubiquitin, an adenylate cyclase stimulating polypeptide probably universal in living cells. Biochemistry14: 2214–2218(1975).PubMedCrossRefGoogle Scholar
  10. 10.
    Audhya, T.; Scheid, M.P.; Goldstein, G.: Contrasting biological activities of thymopoietin and splenin, two closely related polypeptide products of thymus and spleen. Proc. natn. Acad. Sci. USA81: 2847–2849(1984).CrossRefGoogle Scholar
  11. 11.
    Scheid, M.; Goldstein, G.; Hammerling, U.; Boyse, E.A.: Lymphocyte differentiation from precursor cells in vitro. Ann. N.Y. Acad. Sci.249: 531–540(1975).PubMedCrossRefGoogle Scholar
  12. 12.
    Scheid, M.P.; Goldstein, G.; Boyse, E.A.: Differentiation of T cells in nude mice. Science190: 1211–1213 (1975).CrossRefGoogle Scholar
  13. 13.
    Boyse, E.A.; Abbott, J.: Surface reorganization as an initial inductive event in the differentiation of prothymocytes to thymocytes. Fed. Proc.34: 24–27(1975).PubMedGoogle Scholar
  14. 14.
    Scheid, M.P.; Goldstein, G.; Boyse, E.A.: The generation and regulation of lymphocyte populations: evidence from differentiative induction systems in vitro. J. exp. Med.147: 1727–1743 (1978).PubMedCrossRefGoogle Scholar
  15. 15.
    Goldstein, G.; Scheid, M.P.; Boyse, E.A.; Schlesinger, D.H.; Van Wauwe, J.: A synthetic pentapeptide with biological activity characteristic of the thymic hormone thymopoietin. Science204: 1309–1310(1979).PubMedCrossRefGoogle Scholar
  16. 16.
    Dautry-Varsat, A.; Lodish, H.F.: The Golgi complex and the sorting of membrane and secreted proteins. Trends Neurosci.6: 484–490 (1983).CrossRefGoogle Scholar
  17. 17.
    Storrie, B.; Goldstein, G.; Boyse, E.A.; Hammerling, U.: Differentiation of thymocytes: evidence that induction of the surface phenotype requires transcription and translation. J. Immun.116: 1358–1362(1976).PubMedGoogle Scholar
  18. 18.
    Rothenberg, E.; Boyse, E.A.: Synthesis and processing of molecules bearing thymus leukemia antigen. J. exp. Med.150: 777–791 (1979).PubMedCrossRefGoogle Scholar
  19. 19.
    Jay, G.; Palladino, M.A.; Khoury, G.; Old, L.J.: Mouse Lyt-2 antigen: evidence for two heterodim- ers with a common subunit. Proc. natn. Acad. Sci. USA79:2654–2657(1982).CrossRefGoogle Scholar
  20. 20.
    Rothenberg, E.; Triglia, D.: Lyt-2 glycoprotein is synthesized as a single molecular species. J. exp. Med.757:365–370(1983).CrossRefGoogle Scholar
  21. 21.
    Tung, J.S.; Shen, F.W.; Deere, M.; Boyse, E.A.: Structure and biosynthesis of Lyt-1. Immunogenetics20: 125–130(1984).PubMedCrossRefGoogle Scholar

Copyright information

© Humana Press Inc. 1985

Authors and Affiliations

  • Edward A. Boyse
    • 1
  1. 1.Memorial Sloan-Kettering Cancer CenterNew YorkUSA

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