Survey of Immunologic Research

, Volume 1, Issue 3, pp 248–254 | Cite as

Virus-specific cytolytic cells

Their in vivo function
  • R. Finberg
  • H. C. J. Ertl
  • M. E. Shapiro


Natural Killer Cell Vesicular Stomatitis Virus Infected Target Infected Target Cell Cytolytic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Perrin, L.H.; Zinkernagel, R.M.; Oldstone, M.B.A.: Immune response in humans after vaccination with vaccinia virus. Generation of a virus specific cytotoxic response by human peripheral blood lymphocytes. J. exp. Med.,145: 949–969 (1977).CrossRefGoogle Scholar
  2. 2.
    Sissons, J.G.P.; Oldstone, M.B.A.: Killing of virus-infected cells by cytotoxic lymphocytes. J. infect. Dis.142: 114–119 (1980).PubMedGoogle Scholar
  3. 3.
    Blanden, R.V.: T cell responses to viral and bacterial infection. Transplant. Rev.19: 56–88 (1974).PubMedGoogle Scholar
  4. 4.
    Doherty, P.C.; Zinkernagel, R.M.: T cell mediated immunopathology in viral infections. Transplant. Rev.19: 89–170 (1974).PubMedGoogle Scholar
  5. 5.
    Yap, K.L.; Ada, G.L.; McKenzie, I.F.C.: Transfer of specific cytotoxic T lymphocytes protects mice inoculated with influenza virus. Nature, Lond.273: 238–240 (1978).CrossRefGoogle Scholar
  6. 6.
    Lin, Y.-L.; Askonas, B.A.: Biological properties of an influenza A virus-specific killer T cell clone. Inhibition of virus replication in vivo and induction of delayed type hypersensitivity reaction. J. exp. Med.154: 225–234 (1981).PubMedCrossRefGoogle Scholar
  7. 7.
    Allison, A.C.: Interactions of antibodies, complement components and various cell types in immunity against viruses and pyogenic bacteria. Transplant. Rev.19: 3–55 (1974).PubMedGoogle Scholar
  8. 8.
    Zinkernagel, R.M.; Rosenthal, R.L.: Experiments and speculation on anti-viral specificity of T and B cells. Immunol. Rev.58: 131–155 (1981).PubMedCrossRefGoogle Scholar
  9. 9.
    Ada, G.L.; Leung, K.-N.; Ertl, H.C.J.: An analysis of effector T cell generation and function in mice exposed to influenza A or sendai virus. Immunol. Rev.58: 6–24 (1981).CrossRefGoogle Scholar
  10. 10.
    Howes, E.L.; Taylor, W.; Mitchison, N.A.; Simpson, E.: MHC matching shows that at least two T cell subsets determine resistance to HSV. Nature, Lond.277: 67–68 (1979).CrossRefGoogle Scholar
  11. 11.
    Keene, J.A.; Forman, J.: Helper, activity is required for the in vivo generation of cytotoxic T lymphocytes. J. exp. Med.155: 768–782 (1982).PubMedCrossRefGoogle Scholar
  12. 12.
    Rosenthal, K.L.; Zinkernagel, R.M.: Inhibition of mice to generate cytotoxic T lymphocytes to vesicular stromatitis virus restricted to H-2 Kk or H-2 Dk. J. Immun.126: 446–451 (1981).PubMedGoogle Scholar
  13. 13.
    Shapiro, M.E.; Burakoff, S.J.; Benacerraf, B.; Finberg, R.W.: Ir gene control of the cytolytic T lymphocyte response to Sendai virus. H-2k mice are low responders to Sendai. J. Immun.127: 2571–2574 (1981).PubMedGoogle Scholar
  14. 14.
    Letvin, N.L.; Kauffman, R.; Finberg, R.W.: T lymphocyte immunity to reovirus: Cellular requirements for generation and role in clearance in primary infection. J. Immun.127: 2334–2339 (1981).PubMedGoogle Scholar
  15. 15.
    Shellam, G.R.; Allan, J.E.; Papadimitrov, J.M.; Bancroft, G.J.: Increased susceptibility to cytomegalovirus infection in beige mutant mice. Proc. natn. Acad. Sci. USA8: 5104–5108 (1981).CrossRefGoogle Scholar
  16. 16.
    Saxena, R.K.; Saxena, Q.B.; Adler, W.H.: Defective T cell response in beige mutant mice. Nature, Lond295: 240–241 (1982).CrossRefGoogle Scholar
  17. 17.
    Lopez, C.: Genetic resistance to herpes virus infections. Role of natural killer cells; in Skamene, Kongshawn, Landy. Genetic control of natural resistance to infection and malignancy, pp. 253–263 (Academic Press, New York 1980).Google Scholar
  18. 18.
    Morris, A.G.; Lin, Y.-L.; Askonas, B.A.: Immune interferon released when a cloned cytotoxic T cell line meets its correct influenza-infected target cells. Nature, Lond.295: 180–182 (1982).CrossRefGoogle Scholar
  19. 19.
    Zinkernagel, R.M.; Althage, A.: Antiviral protection by virus-immune cytotoxic T cells. Infected target cells are lysed before infectious virus progeny is assembled. J. exp. Med.145: 644–651 (1977).PubMedCrossRefGoogle Scholar
  20. 20.
    Wyde, P.P.; Lach, R.B.; Mackler, R.B.; Cate, T.R.; Levy, B.M.: Effects of low and high passage influenza virus in normal and nude mice. Infect Immunity.15: 221–229 (1977).Google Scholar
  21. 21.
    Finberg, R.; Benacerraf, B.: Induction, control and consequences of virus specific cytotoxic T cells. Immunol. Rev.58: 157–180 (1981).PubMedCrossRefGoogle Scholar

Copyright information

© Humana Press Inc. 1982

Authors and Affiliations

  • R. Finberg
    • 1
    • 2
  • H. C. J. Ertl
    • 1
  • M. E. Shapiro
    • 1
  1. 1.Department of PathologyHarvard Medical SchoolBostonUSA
  2. 2.Department of Pathology, Laboratory of Infections DiseaseSidney Farber Cancer InstituteBoston(USA)

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