Serum and hair selenium levels in hereditary nonpolyposis colorectal cancer

  • Margaret A. Tempero
  • Maryce M. Jacobs
  • Henry T. Lynch
  • Curtis L. Graham
  • Alan J. Blotcky
Original Articles


Since low selenium (Se) levels have been identified in some individuals with colon cancer, we evaluated Se levels as a potential marker for this malignancy in a kindred subject to hereditary nonpolyposis colorectal cancer, an autosomal dominant disease. Unaffected family members and spouses were selected randomly for testing. Serum Se levels were performed on dialyzed sera using the neutron activation technique. Hair Se assays were determined by a spectrofluorometric method. Family members were classified as having low, intermediate, or high risk for colon cancer based on family history. There was no correlation between serum and hair Se measurements. There was also no significant difference in hair or serum Se levels between any of the groups, suggesting that serum Se levels do not correlate with hereditary risk for colon cancer. Prospective studies are in progress to evaluate tissue Se levels and serial Se measurements in high risk patients to establish whether Se levels change with the development of colon cancer.

Index Entries

Selenium, levels in hereditary colon cancer trace elements, in hereditary colon cancer colon neoplasms, and Se levels hereditary colon neoplasms, and Se levels cancer, Se levels and colon 


  1. 1.
    R. J. Shamberger, S. A. Tytko, and C. E. Willis,Arch. Environ. Health 31, 231 (1976).PubMedGoogle Scholar
  2. 2.
    R. J. Shamberger, E. Rukovena, A. K. Longfield, S. A. Tytko, S. Deodhar, and C. E. Willis,JNCI 50, 863 (1973).PubMedGoogle Scholar
  3. 3.
    J. E. Wedderburn,N. Z. Vet. J. 20, 56 (1972).PubMedGoogle Scholar
  4. 4.
    M. M. Jacobs, B. Jansson, and A. C. Griffin,Cancer Lett. 2, 133 (1977).PubMedCrossRefGoogle Scholar
  5. 5.
    B. K. Soullier, P. S. Wilson, and N. D. Nigro,Cancer Lett. 12, 343 (1981).PubMedCrossRefGoogle Scholar
  6. 6.
    W. L. Broghamer, K. P. McConnell, and A. L. Blotcky,Cancer 37, 1384 (1976).PubMedCrossRefGoogle Scholar
  7. 7.
    R. R. Cavalieri, K. G. Scott, and E. Sairenji,J. Nucl. Med. 7, 197 (1966).PubMedGoogle Scholar
  8. 8.
    A. J. Blotcky, L. J. Arsenault, and E. P. Rack,Anal. Chem. 45, 1056 (1973).CrossRefGoogle Scholar
  9. 9.
    O. H. Lowry, N. J. Rosebrough, A. L. Farr, and R. J. Randall,J. Biol. Chem. 193, 265 (1951).PubMedGoogle Scholar
  10. 10.
    J. H. Watkinson,Anal. Chem. 38, 92 (1966).PubMedCrossRefGoogle Scholar
  11. 11.
    R. H. Kolstoe, inIntroduction of Statistics for the Behavioral Sciences, The Dorsey Press, Homewood, IL, 1969, pp. 162–164.Google Scholar
  12. 12.
    A. C. Griffin,Adv. in Cancer Res. 29, 419 (1979).CrossRefGoogle Scholar
  13. 13.
    M. M. Jacobs and A. C. Griffin, inInhibition of Tumor Induction and Development, M. S. Zedeck and M. Lipkin, eds., Plenum Press, New York, 1981, pp. 169–188.Google Scholar
  14. 14.
    T. Lawson and D. Birt,Proc. Am. Assoc. Cancer Res. 22, 93A (1981).Google Scholar
  15. 15.
    P. R. Harbach and J. A. Swenberg,Carcinogenesis 2, 575 (1981).PubMedCrossRefGoogle Scholar
  16. 16.
    K. P. McConnell, R. M. Jager, K. I. Bland, and A. J. Blotcky,J. Surg. Oncol. 15, 67 (1980).PubMedCrossRefGoogle Scholar
  17. 17.
    K. P. McConnell, W. L. Broghamer, A. J. Blotcky, and O. J. Hunt,J. Nutr. 105, 1026 (1975).PubMedGoogle Scholar
  18. 18.
    H. T. Lynch, M. W. Shaw, C. W. Magnuson, A. L. Larsen, and A. J. Krush,Arch. Int. Med. 117, 206 (1966).CrossRefGoogle Scholar
  19. 19.
    S. L. Valentine, H. K. Kang, and G. H. Spivey,Environ. Res. 17, 347 (1978).PubMedCrossRefGoogle Scholar
  20. 20.
    R. C. Dickson and R. H. Tomlinson,Clin. Chim. Acta 16, 311 (1967).PubMedCrossRefGoogle Scholar
  21. 21.
    S. Thimaya and S. N. Ganapathy,Sci. Total. Environ. 24, 41 (1982).PubMedCrossRefGoogle Scholar

Copyright information

© The Humana Press Inc 1984

Authors and Affiliations

  • Margaret A. Tempero
    • 1
  • Maryce M. Jacobs
    • 2
  • Henry T. Lynch
    • 3
  • Curtis L. Graham
    • 4
  • Alan J. Blotcky
    • 4
  1. 1.Oncology Section, Department of Internal MedicineOmaha
  2. 2.Eppley Institute for Research in CancerUniversity of Nebraska Medical CenterOmaha
  3. 3.Department of Preventive MedicineCreighton University School of MedicineOmaha
  4. 4.the Research ServiceOmaha Veteran’s Administration Medical CenterOmaha

Personalised recommendations