Immunologic Research

, Volume 13, Issue 2–3, pp 110–116 | Cite as

Probing T-cell signal transduction pathways with the immunosuppressive drugs, FK-506 and rapamycin

  • John J. Siekierka


In addition to their clinical utility in tissue transplantation the immunosuppressive agents FK-506 (Prograf) and rapamycin, have proven to be valuable tools for gaining insight into the biochemistry of T-cell activation. The findings that the protein phosphatase calcineurin and cell cycle control are key elements in T-cell activation and proliferation are the direct result of investigations into the mechanism of action of FK-506 and rapamycin and provide potentially novel therapeutic targets.

Key Words

Immunosuppression Immunophilins T-cell activation Cell cycle 


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Copyright information

© Humana Press Inc. 1994

Authors and Affiliations

  • John J. Siekierka
    • 1
  1. 1.Department of Molecular ImmunologyImmunobiology Research InstituteAnnandaleUSA

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