Immunologic Research

, 14:200 | Cite as

Conformational changes induced in the MHC class I molecule by peptide and β2-microglobulin

  • Joyce C. Solheim
  • James R. Cook
  • Ted H. Hansen


Assembly of the class I MHC molecule is inextricably linked to the antigen presentation function of the class I molecule. Association of the class I MHC molecule with β2-microglobulin (β2m) is a prerequisite for association with the heterodimeric protein TAP, and once peptide is acquired, the class I molecule folds and begins its sojourn to the cell surface. To maintain its folded conformation, class I MHC requires peptide but not β2m, and the sequence of the peptide bound exercises a subtle influence on the structure of the class I molecule that is likely to be a factor in T cell receptor discrimination of MHC/peptide complexes.

Key Words

Major histocompatibility complex β2-microglobulin Conformation Peptide 


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Copyright information

© S. Karge AG 1995

Authors and Affiliations

  • Joyce C. Solheim
    • 1
  • James R. Cook
    • 1
  • Ted H. Hansen
    • 1
  1. 1.Department of GeneticsWashington University School of MedicineSt. Louis(USA)

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