Immunologic Research

, Volume 6, Issue 1–2, pp 1–10 | Cite as

Organization of the human class I major histocompatibility complex genes

  • Beverly H. Koller
  • Dan Geraghty
  • Harry T. Orr
  • Yoji Shimizu
  • Robert DeMars
Structure and Function of Major Histocompatibility Complex Class I Genes and Proteins (Part I), Symposium


Lymphoblastoid Cell Line Major Histocompatibility Complex Gene Histocompatibility Antigen HindIII Fragment Human Class 
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  1. 1.
    Springer, T.A.; Strominger, J.L.: Detergent-soluble HLA antigens contain a hydrophilic region at the COOH-terminus and a penultimate hydrophobic region. Proc. natn. Acad. Sci. USA73: 2481–2485 (1976).CrossRefGoogle Scholar
  2. 2.
    Robb, R.J.; Terhorst, C.; Strorninger, J.L.: Sequence of the COOH-terminal hydrophilic region of histocompatibility antigens HLA-A2 and HLA-B7. J. biol. Chem.253: 5319–5324 (1978).PubMedGoogle Scholar
  3. 3.
    Orr, H.T.; Lopez de Castro, J.A.; Lancet, D.; Strominger, J.L.: Complete amino acid sequence of a papain-solubilized human histocompatibility antigen, HLA-B7. 2. Sequence determination and search for homologies. Biochemistry18: 5711–5720 (1979).PubMedCrossRefGoogle Scholar
  4. 4.
    Malissen, M.; Malissen, B.; Jordan, B.R.: Exon/intron organization and complete nucleotide sequence of an HLA gene. Proc. natn. Acad. Sci. USA79: 893–897 (1982).CrossRefGoogle Scholar
  5. 5.
    Strachan, T.; Sodoyer, R.; Damotte, M.; Jordan, B.R.: Complete nucleotide sequence of a functional class I HLA gene, HLA-A3: implications for the evolution of HLA genes. Eur. molec. Biol. org. J.3: 887–894 (1984).Google Scholar
  6. 6.
    Koller, B.H.; Orr, H.T.: Cloning and complete sequence of an HLA-A2 gene: analysis of two HLA-A alleles at the nucleotide level. J. Immun.134: 2727–2733 (1985).PubMedGoogle Scholar
  7. 7.
    N'Guyen, C.; Sodoyer, R.; Trucy, J.; Strachan, T.; Jordan, B.R.: The HLA-Aw24 gene; sequence, surroundings and comparison with the HLA-A2 and HLA-A3 genes. Immunogenetics21: 479–489 (1985).PubMedCrossRefGoogle Scholar
  8. 8.
    Ways, J.P.; Coppin, H.L.; Parham, P.: The complete primary structure of HLA-Bw58. J. biol. Chem.260: 11924–11933 (1985).PubMedGoogle Scholar
  9. 9.
    Weiss, E.H.; Kuon, W.; Dorner, C.; Lang, M.; Rietmuller, G.: Organization, sequence and expression of the HLA-B27 gene: A molecular approach to analyze HLA and disease associations. Immunobiology170: 367–380 (1985).PubMedGoogle Scholar
  10. 10.
    Seeman, G.H.A.; Rein, R.S.; Brown, C.S.; Ploegh, H.L.: Gene conversion-like mechanisms may generate polymorphism in human class I genes. Eur. molec. Biol. org. J.5: 547–552 (1986).Google Scholar
  11. 11.
    Sodoyer, R.; Damotte, M.; Delovitch, T.L.; Trucy, J.; Jordan, B.R.; Strachan, T.: Complete nucleotide sequence of a gene encoding a functional human class I histocompatibility antigen (HLA-Cw3). Eur. molec. Biol. org. J.3: 879–885 (1984).Google Scholar
  12. 12.
    Kelly, J.H.; Darlington, G.J.: Hybrid genes: molecular approaches to tissue-specific gene regulation. Annu. Rev. Genet.19: 273–296 (1985).PubMedCrossRefGoogle Scholar
  13. 13.
    Biro, P.A.; Periera, D.; Sood, A.K.; deMartinville, B.; Franke, U.; Weissan, S.M.: The structure of the human major histocompatibility locus; in Pernis, Fogel, Immunoglobulin idiotypes. ICN-UCLA Symposium on Molecular and Cell Biology, vol. 20, pp. 315–326 (Academic Press, New York 1981).Google Scholar
  14. 14.
    Orr, H.T.; Bach, F.H.; Ploegh, H.L.; Strominger, J.L.; Kavathas, P.; DeMars, R.: Use of HLA loss mutants to analyze the structure of the human major histocompatibility complex. Nature296: 454–456 (1982).PubMedCrossRefGoogle Scholar
  15. 15.
    Grumet, F.C.; Fish, L.; Mossazadeh, J.; Ness, D.; Dunceman, B.W.: An HLA-B locus probe clarifies endonuclease polymorphism of major histocompatibility complex class I genes. Mol. Biol. Med.1: 501–509 (1983).PubMedGoogle Scholar
  16. 16.
    Orr, H.T.; DeMars, R.: Mapping of class I DNA sequences within the human major histocompatibility complex. Immungenetics18: 489–502 (1983).CrossRefGoogle Scholar
  17. 17.
    Malissen, M.; Damotte, M.; Birnboum, D.; Trucy, J.; Jordan, B.R.: HLA cosmid clones show complete, widely spaced human class I genes with occasional clusters. Gene20: 485–489 (1982).PubMedCrossRefGoogle Scholar
  18. 18.
    Erlich, H.; Lee, J.S.; Petersen, J.W.; Bugawan, T.: DeMars, R.: Molecular analysis of HLA class I and class II antigen loss mutants reveals a homozygous deletion of the DR, DQ, and part of the DP region: implications for class II gene order. Hum. Immunol.16: 205–219 (1986).PubMedCrossRefGoogle Scholar
  19. 19.
    Kavathas, P.; Bach, F.H.; DeMars, R.: Gamma ray-induced loss of expression of HLA and glyoxalase I and alleles in lymphoblastoic cells. proc. natn. Acad. Sci. USA77: 4251–4255 (1980).CrossRefGoogle Scholar
  20. 20.
    Sood, A.K.; Pereira, D.; Weissman, S.M.: Isolation and partial nucleotide sequence of a cDNA clone for human histocompatibility antigen HLA-B by use of an oligodeoxynucleotide primer. Proc. natn. Acad. Sci. USA78: 616–620 (1981).CrossRefGoogle Scholar
  21. 21.
    Koller, B.H.; Sidwell, B.; DeMars, R.; Orr, H.T.: Isolation of HLA locus-specific DNA probes from the 3′-untranslated region. Proc. natn. Acad. Sci. USA81: 5175–5178 (1984).CrossRefGoogle Scholar
  22. 22.
    Fisher, D.A.; Hunt, S.W.; Hood, L.: Structure of a gene encoding a mutrine thymus leukemia antigen, and organization of Tla genes in the BALB/c mouse. J. exp. Med.162: 528–545 (1985).PubMedCrossRefGoogle Scholar
  23. 23.
    Weiss, E.H.; Golden, L.; Fahrner, K.; Mellor, A.L.; Devlin, J.J.; Bullman, H.; Tiddens, H.; Bud, H.; Flavell, R.: Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse. Nature310: 650–655 (1984).PubMedCrossRefGoogle Scholar
  24. 24.
    Shaw, S.; DeMars, R.; Schlossman, S.F.; Smith, P.L.; Lampson, L.A.; Nadler, L.M.: Serologic identification of the human secondary B cell antigens. J. exp. Med.156: 731–743 (1982).PubMedCrossRefGoogle Scholar
  25. 25.
    Olive, D.; Dubreuil, P.; Mawas, C.: Two distinct TL-like molecular subsets defined by monoclonal antibodies on the surface of human thymocytes with different expression on leukemia lines. Immunogenetics20: 253–264 (1984).PubMedCrossRefGoogle Scholar
  26. 26.
    Fauchet, R.; Boscher, M.; Bouhallier, O.; Merdrignac, G.; Genetet, B.; turmel, P.; Charron, D.J.: New class I in man: serological and molecular characterization. Hum. Immunol.17: 3–20 (1986).PubMedCrossRefGoogle Scholar
  27. 27.
    Barbosa, J.A.; Kamarch, M.E.; Biro, P.A.; Weissman, S.M.; Ruddle, F.H.: Identification of human genomic clones coding the major histocompatibility antigens HLA-A2 and HLA-B7 by DNa-mediated gene transfer. Proc. natn. Acad. Sci. USA79: 6327–6331 (1982).CrossRefGoogle Scholar
  28. 28.
    Lemonnier, F.A.; Malissen, M.; Golstein, P.; Le-Bouteiller, P.; Rebai, N.; Damotte, M.; Birnbaum, D.; Callol, D.; Trucy, J.; Jordan, B.R.: Expression of human class I histocompatibility antigens at the surface of DNA-transformed mouse L-cells. Immunogenetics16: 355–361 (1982).PubMedCrossRefGoogle Scholar
  29. 29.
    Shimizu, Y.; Koller, B.; Geraghty, D.; Orr, H.; Shaw, S.; Kavathas, P.; DeMars, R.: Transfer of cloned human class I major histocompatibility complex genes into HLA mutant human lymphoblastoic cells. Mol. cell. Biol.6: 1074–1087 (1986).PubMedGoogle Scholar
  30. 30.
    Orr, H.T.; DeMars, R.: Class I-like HLA genes map telomeric to the HLA-A2 locus in human cells. Nature302: 534–536 (1983).PubMedCrossRefGoogle Scholar
  31. 31.
    Klein, J.: Evolution and function of the major histocompatibility complex: in Parham, Strominger. Histocompatibility antigens, structure and function, pp. 223–239 (Chapman & Hall, London 1982).Google Scholar

Copyright information

© Humana Press Inc. 1987

Authors and Affiliations

  • Beverly H. Koller
    • 1
  • Dan Geraghty
    • 1
  • Harry T. Orr
    • 1
  • Yoji Shimizu
    • 1
  • Robert DeMars
    • 2
  1. 1.Department of Laboratory Medicine and Pathology, Institute of Human GeneticsUniversity of MinnesotaMinneapolis(USA)
  2. 2.Laboratory of GeneticsUniversity of WisconsinMadisonUSA

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