Biological Trace Element Research

, Volume 18, Issue 1, pp 191–199 | Cite as

The metabolism of metals in rat placenta

  • Alberto Mas
  • Bibudhendra Sarkar


The status and transfer of metals across the rat placenta were studied by subcellular and molecular fractionations of this organ at 2 and 24 h after iv injection of radiolabeled metals. The soluble and nuclear fractions showed higher contents of copper and zinc, whereas most of the nickel was associated with the soluble fraction. Cadmium was almost evenly distributed between the microsomal and nuclear fractions. Gel filtration of the soluble fractions showed nickel associated with an unknown low molecular weight form; zinc with high molecular weight proteins; copper with metallothionein, ceruloplasmin, and high molecular weight proteins; and cadmium with high molecular weight proteins and metallothionein.

Index Entries

Pregnant rats placenta metal transfer copper cadmium nickel zinc 


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Copyright information

© The Humana Press Inc. 1988

Authors and Affiliations

  • Alberto Mas
    • 1
    • 2
  • Bibudhendra Sarkar
    • 1
    • 2
  1. 1.Research InstituteThe Hospital for Sick ChildrenToronto
  2. 2.The Department of BiochemistryUniversity of TorontoTorontoCanada

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