Serum selenium, glutathione peroxidase, lipids, and human liver microsomal enzyme activity

A double-blind controlled trial of selenium supplementation
  • P. V. Luoma
  • H. Korpela
  • E. A. Sotaniemi
  • J. Kumpulainen
Original Articles


This study evaluated selenium status in relation to lipid peroxidation, liver microsomal function, and serum lipids in humans. Serum selenium concentration, glutathione peroxidase (GSH-Px) activity, liver microsomal enzyme activity, assessed by plasma antipyrine clearance (AP-CL) rate, and serum lipids were determined in 23 healthy subjects in a double-blind placebo-controlled trial of selenium supplementation. The low selenium concentration (74.0±14.2 μg/L, mean±SD) is attributable to the low selenium content of the diet. Subjects with the lowest selenium levels (n=11) had reduced serum GSH-Px activity, AP-CL rate, high-density lipoprotein cholesterol (HDL-C), and total cholesterol (T-C) as compared with subjects with higher selenium concentrations (n=12). Low AP-CL rates were associated with low HDL-C: T-C ratios. Selenium supplementation, 96 μg/d for 2 wk, increased serum selenium, GSH-Px activity, and the HDL-C: T-C ratio. The results suggest that a low serum selenium level is associated with a decrease in liver microsomal enzyme activity and serum HDL-C and T-C concentrations. Selenium supplementation in subjects with low serum selenium may favorably influence relations between serum lipoproteins connected with the development of atherosclerotic vascular disease.

Index Entries

Selenium selenium supplementation glutathione peroxidase liver microsomal enzymes antipyrine clearance HDL cholesterol cholesterol 


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Copyright information

© The Humana Press Inc 1985

Authors and Affiliations

  • P. V. Luoma
    • 1
    • 2
    • 3
    • 4
  • H. Korpela
    • 1
    • 2
    • 3
    • 4
  • E. A. Sotaniemi
    • 1
    • 2
    • 3
    • 4
  • J. Kumpulainen
    • 1
    • 2
    • 3
    • 4
  1. 1.Clinical Research UnitUniversity of OuluOuluFinland
  2. 2.Department of MedicineUniversity of OuluOuluFinland
  3. 3.Department of PhysiologyUniversity of OuluOuluFinland
  4. 4.Agricultural Research Center LaboratoryJokioinenFinland

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