The effect of methylmercury on prenatal development and trace metal distribution in pregnant and fetal rats
Methylmercuric chloride (MetHg) at the dose of 2.5 mgHg/kg was administered by gavage every other day to pregnant rats from the sixth to the twentieth day of gestation. On the 21st day of gestation, females were sacrificed to allow the evaluation of embryotoxicity and the taking of analytical material. Copper, zinc, iron, and calcium were determined4 by AAS in brain, liver, kidneys, intestine, whole blood, and spleen of pregnant MetHg-exposed, nonpregnant and pregnant control females, and in fetuses as well as in placenta.
Exposure of pregnant rats to MetHg brought about a decrease in the concentration of intestinal iron and calcium compared with control pregnant animals. In whole fetuses where the mother had been exposed to MetHg, the concentrations of calcium and iron were significantly decreased. The skeletal examination showed developmental retardation of fetuses in the MetHg group, which was reflected in enhanced frequency of delayed ossification of the sternebrae, os occipitale, and vertebrae. The copper level in the brains of fetuses from intoxicated mothers was significantly lower and the absolute brain weights were higher than in controls.
Index EntriesMethylmercury, interaction with Cu, Fe, Ca, and Zn calcium, interactions with MetHg pregnant rats, interactions of MetHg, Cu, Fe, Ca, and Zn ossification, of fetus exposed to MetHg, Cu, Fe, Ca, and Zn zinc, interaction with MetHg, Cu, Fe, and Ca copper, interactions with MetHg, Ca, Zn, and Fe iron, interactions with MetHg, Ca, Cu, and Zn rat, MetHg, Ca, Cu, Zn, and Fe interactions in the pregnant fetus, MetHg, Ca, Cu, Zn, and Fe interactions in the rat
Unable to display preview. Download preview PDF.
- 1.T. Täkeuchi, Pathology of Minamata Disease. From Minamata Disease/ Organic Mercury Poisoning/. Study group of Minamata disease Kumamoto Univ., Japan, 1968.Google Scholar
- 3.L. W. Chang, inMechanisms of Neurotoxic Substances, K. N. Presad and A. Vernadakis, eds., Raven Press, New York, 1982, pp. 51–66.Google Scholar
- 4.L. W. Chang and Z. Annau,Neurobehav. Toxicol. Teratol. 18, 405 (1984).Google Scholar
- 5.J. K. Piotrowski and M. J. Inskip, health Effects of Methylmercury, Technical Report No. 24, MARC, London, 1981.Google Scholar
- 6.M. Inouye, K. Hoshino, and U. Murakami,Ann. Rep. Res. Inst. Env. Med. Nagoya Univ. 19, 69, (1972).Google Scholar
- 10.K. S. Khera, inBiogeochemistry of Mercury in the Environment, J. O. Nriagu, ed., Elsevier North-Holland, Amsterdam, 1979, pp. 503–518.Google Scholar
- 11.J. H. R. Kägi and M. Nordberg, inMetallothionein, J. H. R. Kägi and M. Nordberg, eds. Birkhauser, Basel, Experientia Suppl. 34, 1979, pp. 41–124.Google Scholar
- 13.E. A. Brzeźnicka and J. Chmielnicka,Environ. Health Perspect. (part. III) in press.Google Scholar
- 14.A. B. Dawson,Stain Technol. 1, 123 (1926).Google Scholar
- 15.J. G. Wilson, inTeratology: Principles and Techniques, J. G. Wilson and J. Warkany, eds., Univ. of Chicago, Chicago, 1965, pp. 262–277.Google Scholar
- 16.B. J. Winer,Statistical Principles in Experimental Design, McGraw-Hill, New York, 1962.Google Scholar
- 18.S. Siegel,Nonparametric Statistics for the Behavioral Sciences, McGraw-Hill, New York, 1956.Google Scholar
- 19.W. Oktaba,Elementy Statystyki Matematycznej i Metodyka Doświadczalnictwa, PWN, Warszawa, 1974.Google Scholar
- 20.E. A. Brzeźnicka and J. Chmielnicka,Environ. Health Perspect. (part. II) in press.Google Scholar
- 30.R. B. Mailman, inIntroduction to Biochemical Toxicology, E. Hodgson and F. E. Guthrie, eds., Elsevier, Amsterdam, 1982, pp. 224–244.Google Scholar
- 32.B. Barańnski,Environ. Res. submitted.Google Scholar