Skip to main content
SpringerLink
Log in

Effects of acute ethanol administration and cold exposure on the hypothalamic-pituitary-thyroid axis

  • Papers
  • Published:
Endocrine Aims and scope Submit manuscript

Abstract

A single dose of ethanol increases cellular levels of the mRNA encoding thyrotropin-releasing hormone (TRH) in neurons of the paraventricular nucleus (PVN), but blocks the cold-induced increase in the levels of this mRNA. Because the thyrotropic response to cold is dependent upon TRH secretion, we hypothesized that ethanol uncouples the stimulus-induced regulation of TRH secretion from the stimulus-induced regulation of TRH expression. We employed two complementary strategies to test this hypothesis. The first was to determine whether ethanol alters pituitary sensitivity to TRH. Animals given a single intraperitoneal injection of ethanol (3 g/kg) that produced a blood alcohol concentration of nearly 300 mg/100 mL exhibited the same increase in circulating levels of TSH following an intravenous infusion of TRH. Thus, ethanol does not appear to alter pituitary sensitivity to TRH. Second, we tested whether ethanol blocks the cold induction of c-fos expression in TRH neurons of the PVN. Both cold exposure and ethanol induced the expression of c-fos in the PVN and in TRH neurons; the effects of cold and ethanol on c-fos expression were additive. Thus, ethanol clearly does not block the cold activation of TRH neurons.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Aizawa, T. & Greer, M.A. (1981).Endocrinol. 109, 1731–1738.

    CAS  Google Scholar 

  • Annunziato, L., Renzo, G.F.D., Lombardi, G., Scopacasa, F., Schetini, G., Preziosi, P. & Scapagnini, U. (1977).Endocrinol. 100, 738–744.

    CAS  Google Scholar 

  • Arancibia, S., Tapia-Arancibia, L., Assenmacher, I. & Astie, H. (1983).Neuroendocrinol. 37, 225–228.

    Article  CAS  Google Scholar 

  • Arancibia, S., Tapia-Arancibia, L., Assenmacher, I. & Astie H. (1989),Neurosci Lett.,100 169–174.

    Article  PubMed  CAS  Google Scholar 

  • Armstrong, R.C. & Montminy, M.R. (1993).Annu. Rev. Neurosci.,16, 17–29.

    Article  PubMed  CAS  Google Scholar 

  • Blumberg, D.D. (1987).Guide to Molecular Cloning Techniques, Berger, S.L., Kimmel, A.R. (eds.), Academic Press: San Diego. 20–24.

    Chapter  Google Scholar 

  • Brownstein, M.J., Eskay, R.L. & Palkovits, M. (1982).Neuropeptides,2, 197–201.

    Article  CAS  Google Scholar 

  • Covarrubias, L., Uribe, R.M., Mendez, M., Charli, J.L. & Joseph-Bravo, P. (1988).Biochem Biophys Res Commun.,151, 615–622.

    PubMed  CAS  Google Scholar 

  • Curran, T., Gordon, M.B., Rubino, K.L. & Sambucetti, L.C. (1987).Oncogene,2, 79–84.

    PubMed  CAS  Google Scholar 

  • Curran, T. & Franza, B.R. (1988).Cell,55, 395–397.

    Article  PubMed  CAS  Google Scholar 

  • Fink, G., Koch, Y. & Ben-Aroya, N. (1983).Thyrotropin-Releasing Hormone, Griffiths, E.C., Bennette, G.W., (eds.), Raven Press, New York, 127–144.

    Google Scholar 

  • Franklyn, J.A., Wood, D.F., Balfour, N.J., Ramsden, D.B., Docherty, K., Chin, W.W. & Sheppard, M.C. (1987).Endocrinol,120, 2279–2288.

    Article  CAS  Google Scholar 

  • Goodman, R.H. (1990).Annu. Rev. Neurosci. 13, 111–127.

    Article  PubMed  CAS  Google Scholar 

  • Habener, J.F. (1990).Mol. Endocrinol,4, 1087–1094.

    PubMed  CAS  Google Scholar 

  • Hai, T., Curran, T. (1991).Proc. Natl. Acad. Sci. USA.,88, 3720–3724.

    Article  PubMed  CAS  Google Scholar 

  • Ishikawa, K., Kakegawa, T. & Suzuki, M. (1984).Endocrinol. 114, 352–358.

    CAS  Google Scholar 

  • Ishikawa, K., Taniguchi, Y., Inoue, K., Kurosumi, K. & Suzuki, M. (1988).Neuroendocrinol,47, 384–388.

    Article  CAS  Google Scholar 

  • Koibuchi, N., Gibbs, R.B., Suzuki, M. & Pfaff, D.W. (1991).Endocrinology,129, 3208–3216.

    PubMed  CAS  Google Scholar 

  • Koller, K.J., Wolff, R.S., Warden, M.K. & Zoeller, R.T. (1987).Proc. Natl. Acad. Sci. USA,84, 7329–7333.

    Article  PubMed  CAS  Google Scholar 

  • Krulich, L., Giachetti, A., Marchlewska-Koj, A., Hefco, E. & Jameson, H.E. (1977).Endocrinol,100, 496–505.

    CAS  Google Scholar 

  • Le, F., Wilce, P., Cassady, I., Hume, D. & Shanley, B. (1990).Neurosci Lett.,120, 271–274.

    Article  PubMed  CAS  Google Scholar 

  • Le, F.I., Wilce, P.A., Hume, D.A. & Shanley, B.C. (1992).J. Neurochem,59, 1309–1315.

    Article  PubMed  CAS  Google Scholar 

  • Lechan, R.M., Wu, P., Jackson, I.M.D., Wolfe, H., Cooperman, S., Mandel, G. & Goodman, R.H. (1986).Sci.,231, 159–161.

    Article  CAS  Google Scholar 

  • Lee, S.L., Stewart, K. & Goodman, R.H. (1988).J. Biol. Chem.,263, 16604–16609.

    PubMed  CAS  Google Scholar 

  • Lee, S.L., Yang, L.M. & Lin, A. (1993).Ann Meeting Endocrine Soc., Abs 1925.

  • Liao, N., Bulant, M., Nicolas, P., Vaudry, H. & Pelletier, G. (1985).neurosci. Lett.,85, 24–28.

    Article  Google Scholar 

  • Liposits, Z., Paull, W.K., Wu, P., Jackson, I.M.D. & Lechan, R.M. (1987).Histochem,88, 1–10.

    Article  CAS  Google Scholar 

  • Martin, J.B. & Reichlin, S. (1987).Clinical Neuroendocrinology, Contemporary Neurology, F.A. Davis Company. 759.

  • Mirell, C.J., Yanagisawa, M., Lau, R., Pekary, A.E., Chin, W.W. & Hershman, J.M. (1987).Mol. Endocrinol,1, 408–412.

    PubMed  CAS  Google Scholar 

  • Morgan, J.I. & Curran, T. (1991).Annu. Rev. Neurosci.,14, 421–451.

    Article  PubMed  CAS  Google Scholar 

  • Mori, M. & Yamada, M. (1987).J. Endocrinol,114, 443–448.

    PubMed  CAS  Google Scholar 

  • Nudel, U., Zakut, R., Shani, M., Neuman, S., Levy, Z. & Yaffe, D. (1983).Nuc Acid Res.,11, 1759–1771.

    Article  CAS  Google Scholar 

  • Palkovits, M., Eskay, R.L. & Brownstein, M.J. (1982).Endocrinol,110, 1526–1528.

    CAS  Google Scholar 

  • Petersen, S.L., McCrone, S., Coy, D., Adelman, J.P. & Mahan, L.C. (1993).Endocrine J. (In Press).

  • Portolés, M., Sanchis, R. & Guerri, C. (1985).Med Sci.,13, 615–616.

    Google Scholar 

  • Rage, F., Lazaro, J.-B., Benyassi, A., Arancibia, S. & Tapia-Arancibia, L. (1994).J. Neuroendocrinology,6, 19–23.

    Article  CAS  Google Scholar 

  • Rondeel, J.M.M., deGreef, W.J., Schoot, P. v.d., Karels, B., Klootwijk, W. & Visser, T.J. (1988).Endocrinol,123, 523–527.

    CAS  Google Scholar 

  • Rondeel, J.M.M., deGreef, W.J., Vaart, P.D.M. v.d., Schhot, P. v.d. & Visser, T.J. (1989).Endocrinology,125, 971–975.

    PubMed  CAS  Google Scholar 

  • Rondeel, J.M.M., deGreef, W.J., Hop, W.C.J., Rowland, D.L. & Visser, T.J. (1991).Neuroendocrinology,54, 477–481.

    Article  PubMed  CAS  Google Scholar 

  • Sagar, S.M., Sharp, F.R. & Curran, T. (1988).Science,240, 1328–1331.

    Article  PubMed  CAS  Google Scholar 

  • Schettini, G., Quattrone, A., Renzo, G.D., Lombardi, G. & Preziosi, P. (1979).Eur. J. Pharmacol.,56, 153–157.

    Article  PubMed  CAS  Google Scholar 

  • Segersen, T.P., Kauer, J., Wolfe, H.C., Mobtaker, H., Wu, P., Jackson, I.M.D. & Lechan, R.M. (1987).Sci.,238, 78–80.

    Article  Google Scholar 

  • Shupnik, M.A., Greenspan, S.L. & Ridgway, E.C. (1986).J. Biol. Chem.,261, 12675–12679.

    PubMed  CAS  Google Scholar 

  • Shupnik, M.A. & Ridgway, E.C. (1987).Endocrinol,121, 619–624.

    CAS  Google Scholar 

  • Squires, R.F., Saederup, E., Crawley, J.N., Skolnick, P. & Paul, S.M. (1984).Life Sci.,35, 1439–1444.

    Article  PubMed  CAS  Google Scholar 

  • Szabo, M. & Frohman, L.A. (1977).Endocrinol,101, 1023–1033.

    CAS  Google Scholar 

  • Terry, L.C. (1986).Neuroendocrinol,42, 102–108.

    Article  CAS  Google Scholar 

  • Uribe, R.M., Charli, J.L., Rendondo, J.L., Martinez-Esclera, G., Aceves, C., Covarrubias, L. & Joseph-Bravo, T. (1991).Annu Meeting Endocrine Soc., 1991:p. 134, Abstract 413.

  • Uribe, R.M., Redondo, J.L., Charli, J.L. & Joseph-Bravo, P. (1993).Neuroendocrinol,58, 140–145.

    Article  CAS  Google Scholar 

  • Yamada, M., Rogers, D. & Wilber, J.F. (1989).Neuroendocrinol,50, 560–563.

    Article  CAS  Google Scholar 

  • Young, W.S.I. & Zoeller, R.T. (1987).Cell Mol Neurobiol.,7, 353–366.

    Article  PubMed  CAS  Google Scholar 

  • Zoeller, R.T., Kabeer, N. & Albers, H.E. (1990).Endocrinol,127, 2955–2962.

    CAS  Google Scholar 

  • Zoeller, R.T. & Rudeen, P.K. (1992).Molec Brain Res.,13, 321–330.

    Article  PubMed  CAS  Google Scholar 

  • Zoeller, R.T., Kabeer, N. & Albers, H.E. (1993).Amer. Zool.,33, 244–254.

    CAS  Google Scholar 

  • Zoeller, R.T. & Fletcher, D.L. (1994).Molec Brain Res.,24, 185–191.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Anatomy and Neurobiology, University of Missouri School of Medicine, M304, Medical Science Building, 65212, Columbia, Missouri

    Agnes Simonyi, Olimpia Butnariu, P. Kevin Rudeen, Sue McCrone & Sandra L. Petersen

  2. Neuroscience and Behavior Program and Department of Biology, University of Massachusetts, Morrill Science Center, 01003, Amherst, Massachusetts, U.S.A.

    R. Thomas Zoeller & Don L. Fletcher

Authors
  1. R. Thomas Zoeller
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Agnes Simonyi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Olimpia Butnariu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Don L. Fletcher
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P. Kevin Rudeen
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Sue McCrone
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Sandra L. Petersen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zoeller, R.T., Simonyi, A., Butnariu, O. et al. Effects of acute ethanol administration and cold exposure on the hypothalamic-pituitary-thyroid axis. Endocr 3, 39–47 (1995). https://doi.org/10.1007/BF02917447

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02917447

Keywords

Search

Navigation