Biological Trace Element Research

, Volume 21, Issue 1, pp 207–212 | Cite as

The effects of cadmium on zinc absorption in isolated rat intestinal preparations

  • Daphne E. Coppen-Jaeger
  • Michael Wilhelm
Section 3 Bioavailability, Metabolism, and Distribution


The effect of cadmium on zinc absorption was studied using an isolated vascularly and luminally perfused rat intestinal preparation.65Zn as well as Zn and Cd (both as the chloride salt) were added to the luminal perfusion medium (LPM) at varying concentrations. Over a 90-min period, the amount of Zn appearing in the vascular perfusion medium (VPM) and that retained by the tissue post-perfusion was estimated. Cd at all levels studied (0.03, 0.10, 1.0, and 10.0 μg/mL) reduced the amount of Zn appearing in the VPM in comparison with control perfusions (no detectable Cd in the LPM) when the initial Zn concentration was 5 μg/mL. Similarly, with an initial Zn concentration of 10 or 20 μg/mL, the amount of Zn appearing in the VPM was reduced when the Cd concentration was 0.1 or 1.0 μg/mL. With these same Zn concentrations, the amount of Zn retained by the tissue was higher when the Cd concentration was 10 μg/mL. These results demonstrate that Cd at low concentrations is capable of reducing Zn appearance in the VPM.

Index Entries

Zinc cadmium absorption intestinal perfusion rat 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    E. Weigand and M. Kirschgessner,J. Nutr. 110, 469 (1980).PubMedGoogle Scholar
  2. 2.
    D. E. Coppen and N. T. Davies,Brit. J. Nutr. 57, 35 (1987).PubMedCrossRefGoogle Scholar
  3. 3.
    E. C. Foulkes,Toxicology 37, 117 (1985).PubMedCrossRefGoogle Scholar
  4. 4.
    G. Drasch,Sci. Tot. Environ. 26, 11 (1983).Google Scholar
  5. 5.
    D. E. Coppen and N. T. Davies,Quart. J. Exp. Physiol. 73, 595 (1988).Google Scholar
  6. 6.
    H. P. Schedl,Gut 7, 159 (1966).PubMedCrossRefGoogle Scholar
  7. 7.
    L. Steel,Trace Element Metabolism in Man and Animals—IV, J. McHowell, J. M. Gawthorne and C. L. White, eds., Springer-Veslag, Berlin, Heidelberg, New York, Canberra, 1981, pp. 117–121.Google Scholar
  8. 8.
    P. J. Hanson and D. S. Parsons,J. Physiol. 255, 775 (1976).PubMedGoogle Scholar
  9. 9.
    J. E. Hoadley and R. J. Cousins,Proc. Soc. Expl. Biol. Med. 180, 296 (1985).Google Scholar
  10. 10.
    B. Bundscherer, W. A. Rambeck, W. E. Kollmer, and H. Zucker,Zeitschrift fuer Ernaehrungswissenschaft 24, 73 (1985).CrossRefGoogle Scholar
  11. 11.
    L. Friberg, T. Kjellström, and G. F. Nordberg,Handbook on the Toxiology of Metals, vol. II, L. Friberg, G. F. Nordberg, and V. B. Vouk, eds. Elsevier, Amsterdam, New York, and Oxford, 1986, pp. 135–139.Google Scholar

Copyright information

© The Humana Press Inc. 1989

Authors and Affiliations

  • Daphne E. Coppen-Jaeger
    • 1
  • Michael Wilhelm
    • 1
  1. 1.Institute for ToxicologyUniversity of DuesseldorfDuesseldorf 1FRG

Personalised recommendations