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Biological Trace Element Research

, Volume 24, Issue 2–3, pp 223–231 | Cite as

Effect of dietary tin deficiency on growth and mineral status in rats

  • Katsuhiko Yokoi
  • Mieko Kimura
  • Yoshinori Itokawa
Article

Abstract

To clarify the influence of dietary tin deficiency on growth and mineral status, the following two different synthetic diets were fed to male Wistar rats: group 1—a diet containing 1.99 μg tin/g; group 2—a diet containing 17 ng tin/g. The rats in group 2 showed poor growth, lowered response to sound, and alopecia, with decreased food efficiency compared with rats in group 1. The changes of mineral concentrations in tissues observed in group 2, compared with group 1, are summarized as follows: calcium concentration in lung increased; magnesium concentration in lung decreased; iron concentrations in spleen and kidney increased; iron concentration in femoral muscle decreased; zinc concentration in heart decreased; copper concentrations in heart and tibia decreased; manganese concentrations in femoral muscle and tibia decreased. These results suggest that tin may be essential for rat growth.

Index Entries

Tin tin deficiency alopecia iron mineral status 

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Copyright information

© The Humana Press Inc. 1990

Authors and Affiliations

  • Katsuhiko Yokoi
    • 1
  • Mieko Kimura
    • 1
  • Yoshinori Itokawa
    • 1
  1. 1.Department of Hygiene, Faculty of MedicineKyoto UniversityKyotoJapan

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