Selenium concentrations in the human thyroid gland
- 80 Downloads
Recently, we found that prediagnostic serum selenium concentration was significantly lower for cases developing thyroid cancer (n=43) than for controls. We assumed that redistribution of serum selenium into the affected tissue took place in the prediagnostic period. The present study was carried out to determine the physiological concentration of selenium in the thyroid, since very few data are available in the literature.
The concentrations of selenium in the thyroid (n=45) and liver samples from Norwegians who had died because of acute illness or accidents were determined by hydride generation atomic absorption spectrometry.
The mean selenium concentration was found to be 0.72±0.44 μg/g in the thyroid and 0.45±0.11 μg/g in the liver tissue. The surprisingly high concentration of selenium in apparently normal thyroids indicates that selenium has important functions in this organ. The remarkably broad range, together with the observation that no significant correlation exists between thyroid and liver concentrations, suggest that factors other than the selenium status are important determinants for the selenium concentration in the thyroid gland. This observation is consistent with our hypothesis that in carcinogenesis, prediagnostic processes influence the serum-/thyroid-ratio of selenium.
Index EntriesSelenium thyroid gland liver carcinogenesis
Unable to display preview. Download preview PDF.
- 1.J. T. Salonen, G. Alfthan, J. K. Huttunen, and P. Puska,Amer. J. Epidemiol. 120, 342 (1984).Google Scholar
- 2.W. C. Willett and M. J. Stampfer,Acta Pharmacol. Toxicol. 59 (suppl. 7), 240 (1986).Google Scholar
- 7.National Research Council: Subcommittee on Selenium,Selenium in Nutrition, National Academy Press, Washington, DC, 1983.Google Scholar
- 9.F. Carmignol, P. M. Sinet, and H. Jerome,Biochim. Biophys. Acta 759, 49 (1983).Google Scholar
- 10.P. C. Jocelyn,Biochemistry of the SH Group, Academic Press, London, New York, 1972, p. 269.Google Scholar
- 11.Y. Thomassen and J. Aaseth,Selenium, M. Ihnat, ed. CRC Press Inc., Boca Raton, FL, 1989.Google Scholar
- 12.E. J. Underwood,Trace Elements in Human and Animal Nutrition, Academic Press, New York, 1977, p. 545.Google Scholar
- 13.A. Haugen, Røie, and G. Norheim, Abstracts, 10th Nordic Atomic Absorption Spectroscopy and Trace Element Conference, Turku, Finland Aug. 6–9, 1985, p. 50.Google Scholar
- 14.G. Norheim and R. Haugen,Acta Pharmacol. Toxicol. 59 (suppl. 7) 610 (1986).Google Scholar
- 15.Y. Thomassen, J. Aaseth, G. Norheim, and J. Ringstad,J. Trace Elem. Electrolytes Health Dis. (1989), submitted.Google Scholar
- 21.J. Aaseth and Y. Thomassen,Selenium in Medicine and Biology, Proceedings of the Second International Congress in Trace Elements in Medicine and Biology, France, N. Nève, and A. Favier, eds., W. de Gruyter, Berlin, New York, 1988.Google Scholar
- 24.L. Kosta, V. Zelenko, V. Ravnik, et al., IAEA-SM-175/27,Symposium on nuclear techniques in comparative studies on food and environmental contamination, International Atomic Energy Agency, Vienna, Austria, p. 541.Google Scholar
- 25.G. J. Becket, S. E. Beddows, P. C. Morrice, F. Nicol, and J. R. Arthur,Biochem. J. 248, 443 (1987).Google Scholar
- 26.WHO, IARC Monographs on the evaluation of the carcinogenic risk of chemicals to humans, vol. 27, International Agency for Research on Cancer, Lyon, France 1982, pp. 63–154.Google Scholar