Advertisement

Immunologic Research

, Volume 5, Issue 1, pp 79–88 | Cite as

The Ir-Thy-1 concept: Continuing saga

  • M. B. Zaleski
  • L. J. Quackenbush
  • T. J. Gorzynski
  • J. S. Reichner
Immunogenetics

Keywords

Hybrid Molecule Compatible Class Parental Mouse Helper Cell Subset Lymphocyte Antigen Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Lake, P.; Mitchison, N.A.: Regulatory mechanism in the immune response to cell surface alloantigens. Cold Spring Harb. Symp. quant. Biol., vol. 41, pp. 489–595 (Karger, Basel 1977).Google Scholar
  2. 2.
    Zaleski, M.; Gorzynski, T.; Klein, J.: Effect of H-2 incompatibility between recipient and donor on the magnitude of response to Thy-I antigen. Immunogenetics6: 533–560 (1978).CrossRefGoogle Scholar
  3. 3.
    Lake, P.; Douglas, T.C.: Recognition and control of helper determinants for cell-surface antigen Thy-I. Nature275: 320–322 (1978).CrossRefGoogle Scholar
  4. 4.
    Zaleski, M.; Gorzynski, T.: Non-H-2 antigens serving as carrier determinants in a primary anti-Thy-1 response in mice. Immunol. Commun.9: 309–317 (1980).PubMedGoogle Scholar
  5. 5.
    Zaleski, M.; Klein, J.: Genetic control of the immune response to Thy-1 antigens. Immunol. Rev.38: 120–162 (1978).PubMedCrossRefGoogle Scholar
  6. 6.
    Zaleski, M.; Milgrom, F.: Complementary genes controlling immune response to 0-AKR antigen in mice. J. Immun.110: 1238–1244 (1973).PubMedGoogle Scholar
  7. 7.
    Gorzynski, T.; Reichner, J.; Zaleski, M.: The I genotype and the anti-Thy-1 response: revival of the Ir-Thy-1 concept. Transplantation32: 158–161 (1981).CrossRefGoogle Scholar
  8. 8.
    Zaleski, M.; Reichner, J.: Differences in the requirements for primary anti-Thy-1 responses elicited by intact or by sonicated allogeneic thymocytes. Transpi. Proc.15: 330–332 (1983).Google Scholar
  9. 9.
    Zaleski, M.; Reichner, J.: The Ir-Thy-1 concept: facts and interpretation. Surv. immunol. Res.1: 76–84 (1982).PubMedGoogle Scholar
  10. 10.
    Fuji, H.; Zaleski, M.; Milgrom, F.: Immune response to alloantigens of thymus studied in mice with plaque assay. J. Immun.106: 56–64 (1971).PubMedGoogle Scholar
  11. 11.
    David, C.S.; Lafuse, W.P.: Hybrid Ia antigens: identification, characterization and role in immune responses; in Zaleski, Abeyounis, Kano, Immunobiology of the major histocompatibility complex, pp. 28–43 (Karger, Basel 1980).Google Scholar
  12. 12.
    Reichner, J.; Zaleski, M.: The search for H-2 complementation affecting the anti-Thy-1 response in mice: a progress report. Immunol. Commun.10: 523–531 (1981).PubMedGoogle Scholar
  13. 13.
    Quackenbush, L.J.; Dowjat, W.K.; Zaleski, M.B.: Search for IAtrans-complementation affecting the anti-Thy-1 response in mice: a final report, Immunol. Invest.14: 379–385 (1985).PubMedCrossRefGoogle Scholar
  14. 14.
    Klein, J.; Baxevanis, C.N.; Nagy, Z.A.: Blind spots in the T cell repertoire; in Sasazuki, Tada, Immunogenetics: its application to clinical medicine, pp. 183–195 (Academic Press, Tokyo 1984).Google Scholar
  15. 15.
    Schwartz, R.H.: Associations in T-cell activation. Nature317: 284 (1985).PubMedCrossRefGoogle Scholar
  16. 16.
    McKenzie, I.F.C.; Morgan, G.M.; Sandrin, M.S.; Michaelides, M.M.; Melvold, R.W.; Kohn, H.I.: B6.C-H-2 bm12, a new H-2 mutation in theI region of the mouse. J. exp. Med.150: 1323–1338 (1979).PubMedCrossRefGoogle Scholar
  17. 17.
    McKean, D.J.; Melvold, R.W.; David, C.S.: Tryp-tic peptide comparison of Ia antigen and polypeptides from theI-A mutant B6.C-H-2 bm12 and its congenic parental strain B6. Immunogenetics14: 41–51 (1981).PubMedCrossRefGoogle Scholar
  18. 18.
    Quackenbush, L.J.; Dowjat, W.K.; Zaleski, M.B.: IA mutation affects anti-Thy-1 response in mice. Immunogenetics21: 617–621 (1985).PubMedCrossRefGoogle Scholar
  19. 19.
    Zaleski, M.; Gerzynski, T.; Quackenbush, L.J., Dowjat, W.: In vivo inhibition of anti-Thy-1 response by monoclonal antibody to the IA molecules of the responder. Immunogenetics22: 673–677 (1985).PubMedCrossRefGoogle Scholar
  20. 20.
    Kappler, J.W.; Skidmore, B.; White, J.; Marrack, P.: Antigen-inducible, H-2 restricted interleukin-2-producing T cell hybridomas. J. exp. Med.153: 1198–1214 (1981).PubMedCrossRefGoogle Scholar
  21. 21.
    Ozato, K.; Epstein, S.L.; Henkart, P.; Hansen, T.H.; Sachs, D.: Studies on monoclonal antibodies to mouse MHC products. Transplant. Proc.13: 958–962 (1981).PubMedGoogle Scholar
  22. 22.
    Hammerling, G.J.; Hammerling, U.; Lemke, H.: Isolation of twelve monoclonal antibodies against Ia and H-2 antigens. Serological characterization and reactivity with B and T lymphocytes. Immunogenetics8: 433–445 (1979).CrossRefGoogle Scholar
  23. 23.
    Sprent, J.: Effect of blocking helper T cell induction in vivo with anti-Ia antibodies. possible role of I-A/E hybrid molecules as restriction elements. J. exp. Med.152: 996–1010 (1980).PubMedCrossRefGoogle Scholar
  24. 24.
    Kappler, J.; White, J.; Wegmann, D.; Mustain, E.; Marrack, P.: Antigen presentation by Ia+ B cell hybridomas toH-2 restricted T cell hybridomas. Proc. natn. Acad. Sci. USA79: 3604–3607 (1982).CrossRefGoogle Scholar
  25. 25.
    Řihova, R.; Řiha, I.: Genetic regulation of anti-body response to sheep red blood cells: linkage toH-2 complex. Am. J. reprod. Immunol.1: 168–173 (1981).PubMedGoogle Scholar
  26. 26.
    Vaz, N.M.; Vaz, E.M.; Levine, B.B.: Relationship between histocompatibility (H-2) complex and immune responsiveness to low doses of ovalbumin in the mouse. J. Immun.104: 1572–1574 (1970).PubMedGoogle Scholar
  27. 27.
    Lanzavecchi, A.: Antigen-specific interaction between T and B cells. Nature314: 537–539 (1985).CrossRefGoogle Scholar
  28. 28.
    Zaleski, M.; Gorzynski, T.: Genetic and cellular requirements for primary antibody immune response to Thy-1 antigens in mice. J. Immun.122: 204–206 (1979).Google Scholar
  29. 29.
    Schatten, S.; Drebin, J.A.; Granstein, R.D.; Greene, M.I.: Differential antigen presentation in tumor immunity. Fed. Proc.43: 2460–2464 (1984).PubMedGoogle Scholar
  30. 30.
    Finnegan, A.; Needleman, B.W.; Hodes, R.J.: Antigen processing requirements for T cell activation. Differential requirements for presentation of soluble conventional antigen vs. cell-surface MHC determinants. J. Immun.134: 2960–2965 (1985).PubMedGoogle Scholar
  31. 31.
    Kruisbeek, A.M.; Titus, J.A.; Stephany, D.A.; Gause, B.L.; Longo, D.L.: In vivo treatment with monoclonal anti-I-A antibodies: disappearance of splenic antigen-presenting cell function concommitant with modulation of splenic cell-surface I-A and I-E antigens. J. Immun.134: 3605–3614 (1985).PubMedGoogle Scholar
  32. 32.
    Kromenberg, M.; Malissen, B.; Eisen, H.N.: Genes, structures and function of T lymphocyte antigen receptor. Immunol. today6: 281–286 (1985).CrossRefGoogle Scholar
  33. 33.
    Zaleski, M.; Reichner, J.; Albini, B.: Preliminary analysis of primary and secondary anti-Thy-1 responses clinited by immunization with cell-bound and cell-free antigen. Int. Archs Allergy appl. Immun.73: 263–268 (1984).Google Scholar
  34. 34.
    Loveland, B.E.; McKenzie, I.F.C.: Which T cells cause graft rejection? Transplantation33: 217–220 (1982).PubMedCrossRefGoogle Scholar
  35. 35.
    Dallman, M.J.; Mason, D.W.: Role of thymus-derived and thymus-independent cells in murine skin allograft rejection. Transplantation33: 221–223 (1982).PubMedCrossRefGoogle Scholar
  36. 36.
    Weger, R.A. de; Duliens, H.F.T.; Boer, R.J. de; Otter, W. den: Mathematical analysis of the cellular immune reaction against tumour cells. Immunol. today6: 316–317 (1985).CrossRefGoogle Scholar

Copyright information

© Humana Press Inc. 1986

Authors and Affiliations

  • M. B. Zaleski
    • 1
  • L. J. Quackenbush
    • 1
  • T. J. Gorzynski
    • 2
  • J. S. Reichner
    • 1
  1. 1.Department of MicrobiologyState University of New York at BuffaloBuffalo(USA)
  2. 2.Department of ImmunologyMayo ClinicRochesterUSA

Personalised recommendations