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Vitamin E and selenium supplementation in geriatric patients

A double-blind preliminary clinical trial
  • Matti Tolonen
  • Markku Halme
  • Seppo Sarna
Original Articles

Abstract

Sodium selenate (8 mg/d), organic selenium (50 μg/d) andd-alpha-tocopherol acetate (400 mg/d) were administered for 1 yr to 15 geriatric patients. Fifteen comparable controls received placebo. The mean age of both groups was 76 yr. The patients were assessed every 2 mo independently by two nurses using the Sandoz Clinical Assessment Geriatric-scale (SCAG). The propositae, showed significant improvement in the following SCAG parameters: depression, anxiety, self-care, mental alertness, emotional lability, motivation and initiative, hostility, interest in the environment, fatigue, anorexia, and general impression. A distinct improvement of the general condition was noticed after only 2 mo and the improvement continued up to the end of the 1-yr study period. The high selenium and vitamin E doses were well tolerated; there were no side effects whatsoever.

Index Entries

Selenium supplementation in geriatric patients vitamin E, in geriatric patients geriatrics, vitamin E and Se supplementation in vitamin E and Se supplementation in clinical thial of vitamin E and Se supplementation in geriatric cases 

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Copyright information

© The Humana Press Inc 1985

Authors and Affiliations

  • Matti Tolonen
    • 1
    • 2
  • Markku Halme
    • 1
    • 2
  • Seppo Sarna
    • 1
    • 2
  1. 1.Department of Public HealthUniversity of HelsinkiHelsinkiFinland
  2. 2.Hartola Health CenterHartolaFinland

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