Abstract
Sodium selenate (8 mg/d), organic selenium (50 μg/d) andd-alpha-tocopherol acetate (400 mg/d) were administered for 1 yr to 15 geriatric patients. Fifteen comparable controls received placebo. The mean age of both groups was 76 yr. The patients were assessed every 2 mo independently by two nurses using the Sandoz Clinical Assessment Geriatric-scale (SCAG). The propositae, showed significant improvement in the following SCAG parameters: depression, anxiety, self-care, mental alertness, emotional lability, motivation and initiative, hostility, interest in the environment, fatigue, anorexia, and general impression. A distinct improvement of the general condition was noticed after only 2 mo and the improvement continued up to the end of the 1-yr study period. The high selenium and vitamin E doses were well tolerated; there were no side effects whatsoever.
Similar content being viewed by others
References
Diplock, A. T.,Med. Biol. 62, 2, 78 (1984).
Dowson, J. H.,Brit. J. Psychiatr. 40, 148 (1982).
Venn, R.,Gerontology 29, 185 (1983).
Westermarck, T., and Santavuori, P.,Med. Biol. 62, 2, 148, (1984).
Koivistoinen, P., and Hyvönen, L.,Duodecim 100, 987 (1984).
Stites, D. P., Stobo, J. D., Fudenberg, H. H., and Wells, I. W., eds.:Basic and Clinical Immunology. 4th edition, Large, Los Altos, California, 1982.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tolonen, M., Halme, M. & Sarna, S. Vitamin E and selenium supplementation in geriatric patients. Biol Trace Elem Res 7, 161–168 (1985). https://doi.org/10.1007/BF02916538
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02916538