Effect of salicylate on zinc metabolism in fetal and maternal rats fed normal and zinc-deficient diets
- 26 Downloads
Pregnant rats fed normal and Zn-deficient diets were treated with oral daily doses of 100 and 300 mg/kg salicylic acid from d 16–20 of gestation. This treatment caused a dose-dependent reduction in fetal body weight. Serum Zn concentration in the Zn-deficient dams was increased by salicylate. Zinc content in fetal livers was reduced by salicylate treatment. This effect was more pronounced in the control fetuses. The reduction in fetal liver Zn by salicylate and Zn deficiency was parallel to the reduction in Zn-metallothionein. Total Zn content in fetal kidney was not significantly affected by salicylate and Zn deficiency. Zinc bound to cytoplasmic high-molecular-weight proteins in fetal liver and kidney was not significantly reduced by Zn deficiency and salicylate. Other elements were not affected by salicylate treatment. Some of the fetuses from salicylate-treated Zn-deficient dams developed hydrops and hydronephrosis.
Index EntriesZn-metallothionein, effect of salicylate on, effect of Zn deficiency on hydrops, induction by Zn deficiency and salicylate hydronephrosis, induction by Zn deficiency and salicylate fetal liver fetal kidney
Unable to display preview. Download preview PDF.
- 1.L. G. Sillén,Stability Constants of Metal-Ion Complexes. Suppl. no. 1., The Chemical Society, Burlington House, London, 1971, p. 484.Google Scholar
- 3.J. Vormann and T. Günther (accompanying paper).Google Scholar
- 4.J. Hirate, I. Horikoshi, J. Watanabe, S. Ozaki, and S. Nagase,J. Pharmacol. Dyn. 7, 929 (1984).Google Scholar
- 8.E. L. Potter,Normal and Abnormal Development of the Kidney. Year Book Medical, Chicago 1972, p. 283.Google Scholar