Biological Trace Element Research

, Volume 9, Issue 1, pp 55–64 | Cite as

Effect of salicylate on zinc metabolism in fetal and maternal rats fed normal and zinc-deficient diets

  • Jürgen Vormann
  • Vera Höllriegl
  • Hans-Joachim Merker
  • Theodor Günther
Original Articles


Pregnant rats fed normal and Zn-deficient diets were treated with oral daily doses of 100 and 300 mg/kg salicylic acid from d 16–20 of gestation. This treatment caused a dose-dependent reduction in fetal body weight. Serum Zn concentration in the Zn-deficient dams was increased by salicylate. Zinc content in fetal livers was reduced by salicylate treatment. This effect was more pronounced in the control fetuses. The reduction in fetal liver Zn by salicylate and Zn deficiency was parallel to the reduction in Zn-metallothionein. Total Zn content in fetal kidney was not significantly affected by salicylate and Zn deficiency. Zinc bound to cytoplasmic high-molecular-weight proteins in fetal liver and kidney was not significantly reduced by Zn deficiency and salicylate. Other elements were not affected by salicylate treatment. Some of the fetuses from salicylate-treated Zn-deficient dams developed hydrops and hydronephrosis.

Index Entries

Zn-metallothionein, effect of salicylate on, effect of Zn deficiency on hydrops, induction by Zn deficiency and salicylate hydronephrosis, induction by Zn deficiency and salicylate fetal liver fetal kidney 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    L. G. Sillén,Stability Constants of Metal-Ion Complexes. Suppl. no. 1., The Chemical Society, Burlington House, London, 1971, p. 484.Google Scholar
  2. 2.
    R. M. Hackman and L. S. Hurley,Teratology 30, 225 (1984).PubMedCrossRefGoogle Scholar
  3. 3.
    J. Vormann and T. Günther (accompanying paper).Google Scholar
  4. 4.
    J. Hirate, I. Horikoshi, J. Watanabe, S. Ozaki, and S. Nagase,J. Pharmacol. Dyn. 7, 929 (1984).Google Scholar
  5. 5.
    S. Grisolia, J. Mendelson, and D. Diederich,FEBS Lett. 11, 140 (1970).PubMedCrossRefGoogle Scholar
  6. 6.
    B. L. O’Dell, J. D. Browning, and P. G. Reeves,J. Nutr. 113, 760 (1983).PubMedGoogle Scholar
  7. 7.
    J. C. Smith, Jr., E. G. McDaniel, F. F. Fan, and J. A. Halsted,Science 181, 954 (1973).PubMedCrossRefGoogle Scholar
  8. 8.
    E. L. Potter,Normal and Abnormal Development of the Kidney. Year Book Medical, Chicago 1972, p. 283.Google Scholar

Copyright information

© The Humana Press Inc 1986

Authors and Affiliations

  • Jürgen Vormann
    • 1
  • Vera Höllriegl
    • 1
  • Hans-Joachim Merker
    • 2
  • Theodor Günther
    • 1
  1. 1.Institute of Molecular Biology and BiochemistryFree University of BerlinBerlin 33FRG
  2. 2.Institute of Toxicology and Prenatal PharmacologyFree University of BerlinBerlin 33FRG

Personalised recommendations