Significance of hemodynamic effects on the generation of atherosclerosis

  • Sang-Ho Suh
  • Hyung-Woon Roh
  • Dong-Joo Kim
  • Hyuck-Moon Kwon
  • Byoung Kwon Lee


Atherosclerosis, which is a degenerative vascular disease, is believed to occur in the blood vessels due to deposition of cholesterol or low density hpoprotein (LDL) Atherosclerotic lumen narrowing causes reduction of blood flow due to hemodynamic features Several hypothetical theories related to the hemodynamic effects have been reported. high shear stress theory, low shear stress theory, high shear stress gradient theory, flow separation and turbulence theory, and high pressure theory However, no one theory clearly explains the causes of atherosclerosis The objective of the present study was to investigate the mechanism of the generation of atherosclerosis In the study, the database of Korean carotid and coronary arteries for geometrical and hemodynamic clinical data was established The atherosclerotic sites were predicted by the computer simulations. The results of the computer simulation were compared with the in vivo experimental results, and then the pathogenesis of atherosclerosis by using the clinical data and several hypothetical theories were investigated From the investigation, it was concluded carefully that the mechanism of the generation of atherosclerosis was related to the hemodynamic effects such as flow separation and oscillatory wall shear stress on the vessel walls

Key Words

Atherosclerosis Hemodynamic Hypotheses Comparative Study Hemodynamic Characteristics Vision Technique Computer Simulation 


Alphabetic letters


Coefficient of the diagonal term of the matrix


Convective contributions from the six surrounding control volumes


Source term enhancing the diagonal dominance of the matrix


Pressure [Pa]


Index of Carreau model


Velocity [m/s]


Coordinate [m]

Greek symbols


Dependant variables


Shear rate [l/s]


Apparent viscosity at infinite-shear-rate [Pa.s]


Apparent viscosity at zero-shear-rate [Pa.s]


Characteristic time [s]


Density [kg/m3]



Tensor index


Contributions of the neighbouring control volumes


Control volume whose variables


  1. Caro, C G, Fitz-Gerald, J M and Schroter, R C, 1971, “Atheroma and Arterial Wall Shear Observation, Correlation and Proposal of a Shear Dependent Mass Transfer Mechanism for Atherogenesis,”Proc R. Soc. B, Vol 177, pp 109–159CrossRefGoogle Scholar
  2. Cho, M T, Roh, H W,Suh, S H and Kim, J S, 2002, “Pulsatile Flow Analysis of Newtoman Fluid in Circlular Tube,”KSME (B), Vol 26, No 1, pp 1585–1596Google Scholar
  3. Fox, J A and Hugh, A E, 1966, “Localization of Atheroma a Theory Based on Boundary Layer Separation,”Bi Heart J, Vol 28, No 3, pp 388–399CrossRefGoogle Scholar
  4. Fry, D L, 1972, “Response of the Arterial Wall to Certain Physical Factors Atherogenesis Initiating Factors,” A Ciba Foundation Symp, ASP, Amsterdam, The Neterlands, pp 40–83Google Scholar
  5. Lee, B K, Kwon, H M, Hong, B K, Park, B E, Suh, S H, Cho, M T, Lee, C S, Kim, M C, Kim, C J, Yoo, S S and Kim, H S, 2001, “Hemodynamic Effects on Atherosclerosis-Prone Coronary Artery wall Shear Stress/Rate Distribution and Impedance Phase Angle in Coronary and Aortic Circulation,”Yonser Med J, Vol 42, No 4, pp 375–383Google Scholar
  6. Suh, S H, Roh, H W and Kim, J S, 2003, “Effect of the Velocity Waveform of the Physisologycal Flow on Hemodynamics in the Bufurcated Tube,”KSME International Journal, Vol 17, No 2, pp 296–309Google Scholar
  7. Suh, S H, Roh, H W, Yoo, S S and Kwon, H M, 1996, “Numencal Simulation of Blood Flow in the Human Left Coronary Aitery,”The 9th Int Symp on Trans Phenomena in the Thermal-Fluids Eng, pp 91-96Google Scholar
  8. Texon, M, Impaiato, A M and Helpern, M., 1965, “Role of Vascular Dynamics in the Development of Atherosclerosis,”JAMA, Vol 194, pp 168–172CrossRefGoogle Scholar
  9. Tucker, C and Myion, I C, 2001, “NF-kB Pivotal Medrator or Innocent Bystander in Atherogenesis?”J Clin Invest, Vol 107, No 3, pp 255–264CrossRefGoogle Scholar

Copyright information

© The Korean Society of Mechanical Engineers (KSME) 2005

Authors and Affiliations

  • Sang-Ho Suh
    • 1
  • Hyung-Woon Roh
    • 1
  • Dong-Joo Kim
    • 1
  • Hyuck-Moon Kwon
    • 2
  • Byoung Kwon Lee
    • 3
  1. 1.Department of Mechanical EngineeringSoongsil UniversitySeoulKorea
  2. 2.Department of Internal MedicineCollege of Medicine, Yonset UniversitySeoulKorea
  3. 3.Department of Internal MedicineCollege of Medicine, Inje UniversitySeoulKorea

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