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Significance of hemodynamic effects on the generation of atherosclerosis

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Abstract

Atherosclerosis, which is a degenerative vascular disease, is believed to occur in the blood vessels due to deposition of cholesterol or low density hpoprotein (LDL) Atherosclerotic lumen narrowing causes reduction of blood flow due to hemodynamic features Several hypothetical theories related to the hemodynamic effects have been reported. high shear stress theory, low shear stress theory, high shear stress gradient theory, flow separation and turbulence theory, and high pressure theory However, no one theory clearly explains the causes of atherosclerosis The objective of the present study was to investigate the mechanism of the generation of atherosclerosis In the study, the database of Korean carotid and coronary arteries for geometrical and hemodynamic clinical data was established The atherosclerotic sites were predicted by the computer simulations. The results of the computer simulation were compared with the in vivo experimental results, and then the pathogenesis of atherosclerosis by using the clinical data and several hypothetical theories were investigated From the investigation, it was concluded carefully that the mechanism of the generation of atherosclerosis was related to the hemodynamic effects such as flow separation and oscillatory wall shear stress on the vessel walls

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Abbreviations

A:

Coefficient of the diagonal term of the matrix

C:

Convective contributions from the six surrounding control volumes

SP:

Source term enhancing the diagonal dominance of the matrix

p:

Pressure [Pa]

q:

Index of Carreau model

u:

Velocity [m/s]

x:

Coordinate [m]

ø :

Dependant variables

γ :

Shear rate [l/s]

ηoo :

Apparent viscosity at infinite-shear-rate [Pa.s]

ηo :

Apparent viscosity at zero-shear-rate [Pa.s]

λ :

Characteristic time [s]

ρ :

Density [kg/m3]

1,J:

Tensor index

nb:

Contributions of the neighbouring control volumes

p:

Control volume whose variables

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Authors and Affiliations

  1. Department of Mechanical Engineering, Soongsil University, Seoul, Korea

    Sang-Ho Suh, Hyung-Woon Roh & Dong-Joo Kim

  2. Department of Internal Medicine, College of Medicine, Yonset University, Seoul, Korea

    Hyuck-Moon Kwon

  3. Department of Internal Medicine, College of Medicine, Inje University, Seoul, Korea

    Byoung Kwon Lee

Authors
  1. Sang-Ho Suh
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  2. Hyung-Woon Roh
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  3. Dong-Joo Kim
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  4. Hyuck-Moon Kwon
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  5. Byoung Kwon Lee
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Corresponding author

Correspondence to Sang-Ho Suh.

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Suh, SH., Roh, HW., Kim, DJ. et al. Significance of hemodynamic effects on the generation of atherosclerosis. J Mech Sci Technol 19, 836–845 (2005). https://doi.org/10.1007/BF02916132

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  • DOI: https://doi.org/10.1007/BF02916132

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