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Clinical Reviews in Allergy

, 6:231 | Cite as

Bronchial Challenges

  • Hyman Chai
Article
  • 10 Downloads

Conclusions

It is obvious that challenges of various types, those resulting in bronchoconstriction, those resulting in bronchodilation, and those that prevent bronchoconstriction without producing bronchodilation (cromolyn, as an example) should be part and parcel of the evaluation of the asthmatic. There is no better way than defining cause and effect than providing the patient with a procedure that will demonstrate a significant change in bronchial hyperreactivity when evaluated by challenges, be they inhaled formats, ingested formats, or exposure formats for those individuals who have hyperreactive airways. These challenges (delineated throughout this paper), under exacting research conditions, can be done in an office, provided that the office is equipped with the means to deliver the challenge to the lungs by inhalation, intake of food, exposure in the workplace, or by the taking of certain medications (aspirin is an example). The studies discussed previously indicate the variety of mechanisms providing these challenges, with control subjects and pertinent apparatus to define the pulmonary physiology at any point in time. However, challenges are not without their risks. This should be clearly understood before a challenge is undertaken, be it by inhalation or by ingestion. In the same manner, the challenges directed toward reducing the bronchial hyperreactivity are equally important. Adequate delivery systems and accurate measuring devices are available.

Keywords

Asthma Pulmonary Function Clinical Review Peak Flow Methacholine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Chai, H., Farr, R. S., Froehlich, L. A., Mathison, D. A., McLean, J. A., and Roesenthal, R. B., Sheffer A. L., Spector S. L., Townley R. G. (1975),J. Allergy Clin. Immunol. 56 (4), 323–327.PubMedCrossRefGoogle Scholar
  2. 2.
    Gulsvik, A. and Vale, J. R. (1986),Eur. J. Resp. Dis. 68 (143), 1–7.Google Scholar
  3. 3.
    Nordtoft, E. and Bundgaard, A. (1986),Eur. J. Resp. Dis. 68 (143), 8–10.Google Scholar
  4. 4.
    Bundgaard, A. and Schmidt, A. (1986),Eur. J.Resp. Dis. 68 (143), 11–13.Google Scholar
  5. 5.
    Sovijarvi, A. R. A. (1986),Eur. J. Resp. Dis. 68 (143), 18–21.Google Scholar
  6. 6.
    Munkner, T. and Bundgaard, A. (1986),Eur. J. Resp. Dis. 68 (143), 22–27.Google Scholar
  7. 7.
    Newman-Taylor, A. (1986),Eur. J. Resp. Dis. 68 (143), 35–36.Google Scholar
  8. 8.
    Munkner, T. and Budgaard, A. (1986),Eur. J. Resp. Dis. 68 (143), 44–47.Google Scholar
  9. 9.
    Aas, A. (1986),Eur. J. Resp. Dis. 68 (143), 48–50.Google Scholar
  10. 10.
    Madsen, F., Holestein-Rathkou, L., Frolund, B., Weeke, B., and Svend-sen, U. G. (1986),Allergy 4, 187–195.CrossRefGoogle Scholar
  11. 11.
    Burney, P. G. J., Britton, J. R, Chinn, S., Tatterfield, A. E., Platt, H. S., Papacosta, A. O., and Kelson, M. C. (1986),Brit. Med. J. 292, (7), 1483–1486.Google Scholar
  12. 12.
    Sears, Jones, D. T., Holdaway, M. D., Hewd, C. L., Flannery, E. M., Silva, P. A., and Heubs, G. P. (1986),Thorax 41,(9), 667–670.Google Scholar
  13. 13.
    Valenti, S., Grimm, E., and Brusasco, V. (1985),Respiration 48, 97–102.PubMedCrossRefGoogle Scholar
  14. 14.
    Spector, S. L. (1985),Clin. Rev. Allergy 3, 463–486.PubMedGoogle Scholar
  15. 15.
    Kiyingi, K S., Anderson, S. D., Temple, D. M., and Shaw, J. (1985),Eur. J. Resp. Dis. 66, 256–267.Google Scholar
  16. 16.
    Tonnesen, P. (1985),Allergy 40, 136–140.PubMedCrossRefGoogle Scholar
  17. 17.
    Bergstrand, H., Hegardt, B., Lowhagen, O., Strannegard, and Svedmyr, N. (1985),Allergy 40, 187–197.PubMedCrossRefGoogle Scholar
  18. 18.
    Juniper, E. F., Syty-Golda, M., and Hargreave F. E. (1985),Ann. Allergy 55, (2).Google Scholar
  19. 19.
    Cockroft, D. W., and Berscheid, B. A. (1983),Thorax 38, 55–61.Google Scholar
  20. 20.
    Aquilina, A. T. (1983),Thorax 38, 766–770.PubMedGoogle Scholar
  21. 21.
    Anderson, S., Schorffel, R. E., and Finney, M. (1983),Thorax 38 (4), 284–291.PubMedGoogle Scholar
  22. 22.
    Clague, H., Ahmad, D., Chamberlain, M. J., Morgan, W. K. C., and Vinitski, S. (1983)Thorax 38 (9), 668–675.PubMedGoogle Scholar
  23. 23.
    Hariparsad, D., Wilson, N., Dixon, C., and Silverman, M. (1983),Thorax 58 (4), 258–260.Google Scholar
  24. 24.
    Cockroft, D. W. and Berscheid, B. A. (1983),Thorax 38, 55–61.CrossRefGoogle Scholar
  25. 25.
    Cockroft, D. W. and Berscheid, B. A. (1982),Thorax 37, 133–136.Google Scholar
  26. 26.
    Beil, E., Schachter, M. and Rubin, M. (1985), Ann. Allergy54, (1).Google Scholar
  27. 27.
    Mitsuhashi, M., Tomomasa, T., Tokuyama, K., Morikawa, A., and Kur-oume, T. (1985),Ann. Allergy 54 (4), 17–20.Google Scholar
  28. 28.
    Millman, M., Millman, F. M., Golstein, I. M., and Mercandetti, A. J. (1985),Ann. Allergy 54 (4), 17–20.Google Scholar
  29. 29.
    R. Michael Sly., Shelby, H. Josephs, and Eby, Donna M. (1985),Ann. Allergy 54 (3), 209–212.Google Scholar
  30. 30.
    Hughes, E. C., Gott, P. S., Weinstein, R. C., and Binggali, R. (1985),Ann. Allergy 55, 28–32.PubMedGoogle Scholar
  31. 31.
    Boner, A. L., Antolini, I., Zambellini, A. M., Piemonte, G., and Gaburro, D. (1985),Ann. Allergy 54, 442–445.PubMedGoogle Scholar

Copyright information

© The Humana Press, Inc. 1988

Authors and Affiliations

  • Hyman Chai
    • 1
  1. 1.National Jewish Center for immunology and Respiratory MedicineUniversity of Colorado, and Referral ClinicDenver

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