Abstract
Plasma ascorbic acid (AA) levels were estimated in 20 healthy and 80 sick children suffering from various forms of acute illness of less than one week’s duration. The mean plasma AA level in healthy children was 1.07±0.12 mg/dl. The levels were significantly lower in acute infective illness and where the diet preceding illness had inadequate vitamin C content. There was no significant correlation with malnutrition or anemia. Whether the addition of vitamin C supplements would expedite recovery from acute infective illness needs further evaluation.
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Abbasy MA, Harris LJ, Gray Hill N: Excretion on vitamin C in osteomyelitis. Lancet i: 177, 1937
Jetter WW, Bumbalo TS: Urinary output of vitamin C in active tuberculosis in children. Am J Med Sci 195: 362, 1938
Daum K, Boyd K, Paul WD: Influence of fever therapy on blood level and urinary excretion of ascorbic acid. Proc Soc Exper Biol & Med 40: 129, 1939
Andreae WA, Browne JSL: Ascorbic acid metabolism after trauma in man. Canad M A J 55: 425, 1946
Lund CC, Crandon JH: Human experimental scurvy and the relation of vitamin C deficiency to post-operative pneumonia and wound healing. JAMA 116: 663, 1941
Lund CC: Ascorbic acid, thiamine, riboflavine and nicotinic acid in relation to acute burns in man. Arch Surg 55: 557, 1947
Calder JH, Curtis RC, Fore H: Comparison of vitamin C in plasma and leucocytes of smokers and non-smokers. Lancet 1: 556, 1963
Brook M, Grimshaw J: Cigarette smoking lowers leucocyte and plasma ascorbic acid. Am J Clin Nutr 21: 1254 1968
Dugal LP, Therien M: Ascorbic acid and acclimatization to cold environment. Canad J Res 25, 111, 1949
Dugal LP:In, Cold Injury, 2nd Conf Macy, New York, 1952, p. 85
Bagchi K, Chowdhury S: Role of ascorbic acid in the absorption and utilization of iron. Indian J Med Sci 8, 856, 1954
Vaishwanar PS: Blood ascorbic acid levels of Indians in different age groups. Indian J Med Res 47, 158, 1959
Gupta M, Agarwal KN: Blood vitamin C levels in healthy and malnourished preschool children. Indian Pediatr 9: 220, 1972
Bingol A: Plasma, erythrocyte and leucocyte ascorbic acid concentrations in children with iron-deficiency anemia. J Pediatr 86: 902, 1975
Goldsmith GA: Human requirements for vitamin C and its use in clinical medicine. Ann NY Acad Sci 92: 230, 1961
Pauling L: Vitamin C and the Common Cold. WH Freeman, San Francisco, California, 1970
King EJ: Micro-analysis in Medical Biochemistry, 2nd Edn, J & A Churchill Ltd, London, 1951, p 79
Lowry OH: Biochemical evidence of nutritional status. Physiol Rev 32: 431, 1952
Henry RJ: Vitamin C in Clinical Chemistry —Principles and Technics. Harper and Row, U.S.A., 1964, p 711
WHO study group on iron deficiency anemia. WHO Tech Res Ser No. 182, 1959
Roe JH: Standard Methods of Clinical Chemistry, 1961
Gupta S: Blood ascorbic acid levels in children. Indian Pediatr: 361, 1964
Baker H, Frank O: Vitamin analysis in medicine.In, Modern Nutrition in Health and Disease. Goodhart RS and Shils ME (Eds). Lea and Febiger, Philadelphia. 1973
Manchanda SS, Khanna S, Lal H: Plasma ascorbic acid as an index of vitamin C nutrition. Indian Pediatr 184, 1971
Khalil A: Assessment of ascorbic acid nutritional status in 100 preschool children. Indian Pediatr 21, 1976
Mohan Ram M: Studies on ascorbic acid nutrition. Indian J Med Res 53: 891, 1965
Armitage P: Statistical Methods in Medical Research. Blackwell Scientific, Oxford & Edinburgh, 1971, p 189
Prasad BG: Changes proposed in social classification of Indian families. J Ind Med Assos 55, 198 1970
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Shivpuri, S., Saxena, S. Plasma ascorbic acid levels in children with acute illness. Indian J Pediatr 49, 129–133 (1982). https://doi.org/10.1007/BF02914968
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DOI: https://doi.org/10.1007/BF02914968