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Clinical Reviews in Allergy

, Volume 9, Issue 1–2, pp 47–74 | Cite as

Infection and immunity toPseudomonas

  • Ricardo U. Sorensen
  • Robert L. Waller
  • Jeffrey D. Klinger
Article
  • 21 Downloads

Abstract

Chronic pulmonary infection withP. aeruginosa in CF may result from:
  1. 1.

    An initial failure of clearance mechanisms (increased adherence) leading to the development of a highly compartmentalized inflammatory reaction;

     
  2. 2.

    Inhibition of clearing mechanisms for bacteria present in the bronchial lumen; and

     
  3. 3.

    A largely ineffective, and possibly damaging, hyperactivity of inflammatory cells in the lumen and bronchial wall.

     

The special relationship between the CF host andP. aeruginos, always long-term, and frequently subtle in its complexity, needs further understanding in order to develop new strategies for the treatment of chronic lung infections with this organism.

Keywords

Cystic Fibrosis Alveolar Macrophage Cystic Fibrosis Patient Sputum Sample Bronchial Wall 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Humana Press Inc. 1991

Authors and Affiliations

  • Ricardo U. Sorensen
    • 1
  • Robert L. Waller
    • 2
  • Jeffrey D. Klinger
    • 2
    • 3
    • 4
  1. 1.Department of PediatricsLouisiana State University Medical CenterNew Orleans
  2. 2.Department of PediatricsCase Western Reserve University School of Medicine and Rainbow Babies and Children’s HospitalCleveland
  3. 3.GENE-TRAK SystemsFramingham
  4. 4.Children’s HospitalInfectious Disease DivisionBoston

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